Results 111 to 120 of about 3,565,059 (292)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Processing ergativity in compound light verb constructions: electrophysiological evidence from Hindi

open access: yesFrontiers in Human Neuroscience
IntroductionErgativity marks subject arguments as agents of a transitive event and thereby signals verbal transitivity and influences language comprehension.MethodWe report here on an event-related brain potentials (ERP) study in Hindi, in which we ...
Anna Merin Mathew   +4 more
doaj   +1 more source

USA educator perspectives regarding the nature and value of social and emotional learning [PDF]

open access: yes, 2020
This paper discusses the US educator perspectives regarding the nature and value of Social Emotional Learning (SEL) skills. This research is part of a larger study being conducted by 33 career development investigators from 15 countries.
Blake, Mason   +6 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Friendships for High School Students: With Autism Spectrum Disorder and Without [PDF]

open access: yes, 2015
People with Autism Spectrum Disorder (ASD) experience deficits in social communication, having difficulty with carrying on conversations, abiding by social norms, and feeling empathy towards others.
Young, Alanna
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Why Do Social Skills Matter? [PDF]

open access: yes
In this paper I propose a model where social skills of a manager signal the workers that their e¤ort is productive. In this model …rms with a high productivity of e¤ort hire a socially skilled manager and pay higher wages, and workers hired by these …rms
Suren Basov
core  

Employer and student perspectives on skills for engineers in the twenty first century and beyond [PDF]

open access: yes, 2010
This research focused on skills identified among final year engineering students. It provided evidence of different levels of skills by students and identifies their greatest learning influences in these areas.
Brabazon, Dermot   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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