Results 121 to 130 of about 3,565,059 (292)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The Effect of Early Noncognitive Skills on Social Outcomes in Adolescence [PDF]
This paper investigates the impact of early noncognitive skills on social outcomes in adolescence. The child's attention span, approach, prevailing mood and distractibility in early childhood may be crucial predictors for school achievements, health risk
Coneus, Katja, Laucht, Manfred
core
Type D Personality and Injury Relationship in Collegiate Track Athletes [PDF]
, 2016 The purpose of this study was to examine Type D personality as an internal factor for injury risk in collegiate track athletes. A survey was administered to 275 track athletes across each of the three NCAA divisions. The survey included general questions
Tuxbury, Annmarie
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
“Wonder” Through the Eyes of Empathy: A Middle Grades Teacher’s Guide [PDF]
, 2019 This Practitioner Perspective provides brief definitions to the three main components of empathy (cognitive, affective, and behavioral) and outline the importance of incorporating empathy education into the classroom, specifically looking at the areas of
Bouton, Bobette
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Promoting Social Interaction Skills to Influence the Transition to Employment for Youth with Autism Spectrum Disorders [PDF]
, 2015 Autism Spectrum Disorders (ASD) affect one in 68 children in the United States and are characterized by deficits in social interaction. Decreased social interaction skills limit youth with ASDs’ ability to obtain and maintain a job. Acquisition of needed
Lange, Jennifer Susan
core +1 more source