Results 71 to 80 of about 344,768 (297)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Social Inequality in Every Day Laughing Discourse of Modern Russia

Vestnik MGIMO-Universiteta, 2012
This article deals with the everyday discourse of the social inequality. The author analyses the ways in which humor is used to interpritate the social inequalities and the emergence of new privileged strata.
N. N. Zarubina
doaj   +1 more source

Identifying effect heterogeneity to improve the effiency of job creation schemes in Germany? [PDF]

, 2005
Previous empirical studies of job creation schemes in Germany have shown that the average effects for the participating individuals are negative. However, we find that this is not true for all strata of the population.
Caliendo, Marco, Hujer, Reinhard, Thomsen, Stephan L.   +2 more
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Assessment of social isolation and changes in Parkinson’s disease symptoms during the COVID-19 pandemic: A longitudinal study

Clinical Parkinsonism & Related Disorders
Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson’s disease. Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using ...
Anish Mehta, Samuel Y.E. Ng, Shermyn X.M. Neo, Nicole S.Y. Chia, Ehsan S. Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L. Heng, Z.Y. Xu, K.Y. Tay, W.L. Au, E.K. Tan, Louis C.S. Tan   +12 more
doaj   +1 more source

Equity in an educational boom: Lessons from the expansion and marketization of tertiary schooling in Poland [PDF]

The transformation of Polish economy toward a free market system and related changes on the Polish labour market released the demand for higher education, held for decades at an artificially low level.
Herbst, Mikolaj, Rok, Jakub
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Habilidades cognitivas: transmisión intergeneracional por niveles socioeconómicos

Estudios Económicos, 2008
Using the ENNViH 2002 survey, a switching model shows that signifi- cant differences exist in the formation of infant cognitive ability across Mexican social strata.
David Mayer Foulkes, María Fernanda López Olivo, Edson Serván Mori   +2 more
doaj  

Revisiting the Criteria and Indicators for Identifying the Middle Class within Contemporary Russian Society (before the Social and Economic Crisis of 2014)

Oriental Studies, 2018
The article deals with the problem of delineating the middle strata of Russian society in the context of the social and economic crisis and  assesses the correlation of the differences in social positions of  middle class representatives as a criterion ...
D. A. Lushnikov, A. V. Volchinski
doaj   +1 more source

A fair pivotal mechanism for nonpecuniary public goods [PDF]

The Clarke pivotal mechanism is inappropriate for nonpecuniary public goods, because the assumption of quasilinear utility is invalid, and because the mechanism gives disproportionate influence to wealthier voters.
Pivato, Marcus
core   +1 more source