Results 131 to 140 of about 5,074,861 (337)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sender- and Receiver-specific blockmodels [PDF]
Journal of Social Structure, 2015 Zhi Geng, Krzysztof Nowicki
doaj +1 more source
Variation in communicative complexity in relation to social structure and organization in non-human primates. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 Aureli F, Schaffner CM, Schino G.
europepmc +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The role of social structure and dynamics in the maintenance of endemic disease. [PDF]
Behav Ecol Sociobiol, 2021 Silk MJ, Fefferman NH.
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Risk in New Sexual Relationships: Trajectories of Protection* [PDF]
Journal of Social Structure, 2018 David C. Bell
doaj +1 more source
Assessing social structure: a data-driven approach to define associations between individuals. [PDF]
Mamm Biol, 2022 Tavares SB +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source