Results 131 to 140 of about 1,111,789 (314)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hierarchy in Mixed Relation Networks: Warfare Advantage and Resource Distribution in Simulated World-Systems [PDF]

Journal of Social Structure, 2013
Jacob Apkarian, Jesse B. Fletcher, Christopher Chase-Dunn, Robert A. Hanneman   +3 more
doaj   +1 more source

The effect of prey abundance and fisheries on the survival, reproduction, and social structure of killer whales (Orcinus orca) at subantarctic Marion Island. [PDF]

Ecol Evol, 2023
Jordaan RK, Oosthuizen WC, Reisinger RR, de Bruyn PJN.   +3 more
europepmc   +1 more source

Social Type and Social Structure

Japanese Sociological Review, 1958
Most of sociologists in establishing social types applied chiefly the general scheme of social relations. For example, Tonnies' “Gemeinschaft” and “Gesellschaft, ” Durkheim's “solidalite mecanique” and “solidalite organique, ” Gierke's “Herrschaft” and “Genossenschaft” etc.Although on may find sociologists' tentatives done from the point of view of ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sender- and Receiver-specific blockmodels [PDF]

Journal of Social Structure, 2015
Zhi Geng, Krzysztof Nowicki
doaj   +1 more source

Flexibility in the social structure of male chimpanzees (Pan troglodytes schweinfurthii) in the Budongo Forest, Uganda. [PDF]

R Soc Open Sci, 2022
Badihi G, Bodden K, Zuberbühler K, Samuni L, Hobaiter C.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mission, Structure, and Management of Social Entrepreneurial organizations

, 2017
Key learning points from the chapter: Class 1: Managing Social Entrepreneurial Organizations. This section will provide you with insight to some of the ways in which social enterprises are seen through the lens of existing management theories.
Carey, Charlotte, Hill, Inge
core  

Becoming urban: How city life shapes the social structure and genetics of ants. [PDF]

Mol Ecol, 2022
Janda M.
europepmc   +1 more source