Results 91 to 100 of about 1,503,791 (308)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Broadening the Justifications for Inclusive Conservation: Values Associated With Nature's Contributions to People

Conservation Letters
Overlooking the diverse values associated with Nature's Contributions to People (NCP) undermines conservation efforts. To examine this underresearched association, we combined the NCP and plural valuation frameworks to investigate how values are ...
Milena Gross, Henrik von Wehrden, Tuyeni Heita Mwampamba, John Sanya, Jasmine Pearson, Jennifer Kasanda Sesabo, Maraja Riechers, Ugo Arbieu, Katrin Böhning‐Gaese, Berta Martín‐López   +9 more
doaj   +1 more source

Applying social-ecological system resilience principles to the context of woody vegetation management in smallholder farming landscapes of the Global South

Ecosystems and People
Woody vegetation diversity is declining due to human-induced land-use changes, mainly agricultural expansion and intensification, deforestation, forest degradation and urbanisation.
Girma Shumi, Jacqueline Loos, Joern Fischer   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ecology and the Common Good: Sustainability and Catholic Social Teaching [PDF]

, 2007
In recent years official Roman Catholic documents have addressed the ecological crisis from the perspective of Catholic social teaching. This expansion of Catholic social thought addresses the social and ecological question.
Butkus, Russell, Kolmes, Steven
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

An examination of the occurance of work-related musculoskeletal disorders (WMSDS) and symptoms among small scale construction workers in WINDHOEK, Namibia

Social Sciences and Humanities Open
Even though the topic has been the focus of numerous global researches, few studies have examined the incidence of WMSDs symptoms among small-scale construction workers in developing countries of Africa.
Pedzisai Kowe, Robson Spencer Nyamuziwa, Amato Chireshe, Leon Poshai, Steven Jerie, Mark Makomborero Matsa, Shadreck Matindike, Tapiwa Shabani, Takunda Shabani, John Hove   +9 more
doaj   +1 more source

Sustainability in the product design: A review of recent development based on LCA [PDF]

, 2018
In order to achieve sustainable product design process, aspects such of environmental, economic and social should be balanced. This paper discussed on sustainability of product design, conceptual basis of life cycle assessment (LCA), review of LCA at ...
Hassan, Mohd Fahrul, Hemdi, Abdul Rahman, Mahmood, Salwa, Mat Saman, Muhamad Zameri   +3 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A holistic approach to sustainability in higher education institutes: social, economic, educational, and mobility perspectives

Frontiers in Education
Higher education institutions (HEIs) are pivotal in driving the transition to sustainability. HEIs educate future generations and adopt sustainable practices, setting an example for private and public sector organizations.
Zohar Barnett-Itzhaki, Zohar Barnett-Itzhaki, Sigal Tifferet, Sigal Tifferet, Yaeli Etstein, Yaeli Etstein, Inna Gefen, Inna Gefen, Oded Ravid, Oded Ravid, Guy Barokas, Guy Barokas, Iris Vilnai-Yavetz, Iris Vilnai-Yavetz, Gal Hagit Carasso Romano, Adi Levi, Adi Levi   +16 more
doaj   +1 more source