Results 121 to 130 of about 38,947,931 (334)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Complex behavior of individuals and collectives in a social system: An introduction to exploratory computational experimental methodology based on multi-agent modeling. [PDF]
Ann Oper Res, 2023 Zheng X.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Resilience, Adaptability and Transformability in Social–ecological Systems
, 2004 . The concept of resilience has evolved considerably since Holling’s (1973) seminal paper. Different interpretations of what is meant by resilience, however, cause confusion.
B. Walker +3 more
semanticscholar +1 more source
New Zealand’s Social Assistance System: Financial Incentives to Work [PDF]
This paper is a stock take of the financial incentives to work present in New Zealand’s social assistance system. The purpose of this paper is to provide a basis for research on problems facing the social assistance system and dilemmas that would be ...
Patrick Nolan
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Temporal division of labor in an aphid social system. [PDF]
Sci Rep, 2021 Shibao H, Kutsukake M, Fukatsu T.
europepmc +1 more source
Social insurance – a social system
Scientific works "Adilet", 2020 The article discusses in detail the problems of the system of social justice. Three levels of the social protection system in the Republic of Kazakhstan are shown. The experience of using the compulsory social insurance system, which has been in effect in the Republic of Kazakhstan since 2005, has been studied.
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source