Results 161 to 170 of about 20,876,453 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Applications of synergetics in psychology: interpersonal synchrony in social systems. [PDF]

Front Netw Physiol
Tschacher W.
europepmc   +1 more source

Deep Intelligence-Driven Efficient Forecasting for the Agriculture Economy of Computational Social Systems.

Comput Intell Neurosci, 2022
Li X, Li X, Jiang J.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

If We Build It, Will They Use It? Aligning Resource Recovery Design with Place-Based Social Systems. [PDF]

ACS Environ Au
Sudweeks JD, Rosko H, Landsman MR, Cubas F, Rowles LS.   +4 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Estudio Longitudinal Social de Chile 2018

ELSOC has been designed to evaluate how Chileans think, feel, and behave regarding a set of social issues related to conflict and social cohesion in Chile.
Reproducible Research, Centre for Social Conflict and Cohesion Studies COES
core   +1 more source

Complexity in economic and social systems: cryptocurrency market at around COVID-19 [PDF]

Entropy (Basel), 2020
Drożdż S, Kwapień J, Oświęcimka P, Stanisz T, Wątorek M.   +4 more
europepmc   +2 more sources

Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems. [PDF]

J Neurosci
Watts DA, Allsop AS, Compton S, Zhang X, Noah JA, Hirsch J.   +5 more
europepmc   +1 more source

How disease constrains the evolution of social systems. [PDF]

Proc Biol Sci, 2020
Udiani O, Fefferman NH.
europepmc   +1 more source