Results 121 to 130 of about 12,713,785 (351)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Capitalism’s Cynical Leviathan: Cynicism, Totalitarianism, and Hobbes in Modern Capitalist Regulation [PDF]

open access: yes, 2008
In this paper I have tried to show the symbiotic relationship between discursive systems of totalitarianism and cynicism. Whether speaking of a social Leviathan a la Hobbes or localized capitalist regulation each relies upon the symbiotic combination of ...
Bloom, Peter
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Geopolítica e progresso econômico no Brasil

open access: yesMeridiano 47, 2017
This paper intents to show the relationship between the Brazilian geopolitical thought with the economics progress, working for industrialization. Beyond the paper wishes to known why the Brazilian Army searched immediately the geopolitics thought in ...
José Alexandre Altahyde Hage
doaj  

An Investigation into the Economic Thought of Medieval Arab-Islamic Scholars and Enlightenment Philosophers [PDF]

open access: yes, 2019
This student-faculty collaborative research project focused on the contributions to economic thought of two distinct groups: medieval Arab-Islamic scholars and Enlightenment philosophers.
Clayeux, Riley E., Grant, Randy R.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The social criticism in the work of Saadi Shirazi [PDF]

open access: yesKom: Časopis za Religijske Nauke, 2017
A symbolic expression has been an important method of expressing opinion, criticism or indignation in the history of philosophy. This kind of literary expression implicitly points to, among other, educational, pedagogical, moral, political, and ...
Halilović Muamer
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Philosophical and social aspects of al Ya'qubi's history [PDF]

open access: yesKom: Časopis za Religijske Nauke, 2019
Ya'qubi, the great 9th century Muslim historian and geographer, left significant works behind. However, his innovative approach to exploring history is what he is particularly famous for.
Halilović Muamer
doaj  

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