Results 71 to 80 of about 3,635,145 (314)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Post [PDF]

, 2005
About the book: Asserting the need for social science historians to examine their own field, this wide-ranging volume offers an intellectual history and critical evaluation of interdisciplinary social science and social science historiography.
Vincent, David
core  

A Discussion of Social Protection and Private Insurance [PDF]

, 1994
[Excerpt] This is a thoughtful and thought-provoking paper, informative and interesting. I learned a lot from reading this and have already passed it on to others.
Fields, Gary S
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The False Promise of Thought Experimentation in Moral and Political Philosophy [PDF]

, 2017
Prof. Miščević has long been an ardent defender of the use of thought experiments in philosophy, foremost metaphysics, epistemology and philosophy of mind.
Klampfer, Friderik
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

From data to detection: Developing a corpus and training language models for the identification of anti-refugee narratives in Spanish

Array
This study addresses the automatic detection of negative anti-refugee messages in Spanish texts, using language models based on pre-trained Transformers models.
Jacinto Mata, Estrella Gualda, Victoria Pachón, Carolina Rebollo, Juan L. Domínguez   +4 more
doaj   +1 more source

The social criticism in the work of Saadi Shirazi [PDF]

Kom: Časopis za Religijske Nauke, 2017
A symbolic expression has been an important method of expressing opinion, criticism or indignation in the history of philosophy. This kind of literary expression implicitly points to, among other, educational, pedagogical, moral, political, and ...
Halilović Muamer
doaj  

Are People Rational? [PDF]

, 2017
. It is common for Bertrand Russell’s admirers to repeat his many quips about other people’s lack of good sense, for example, “most people would die sooner than think – in fact, they do so.”1 But it is less common for them to assert that this view is ...
Ongley, John
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source