Results 81 to 90 of about 28,121,044 (303)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
IMAGE" OF THE PAST AND PRESENT IN THE REPRESENTATIONS OF NIZHNY NOVGOROD
Вестник Мининского университета, 2017 Awareness of the historical past, its evaluation and interpretation by society has important scientific value, as the identity of any nation begins with the history.
O. A. Nemova +2 more
doaj +2 more sources
Social Work/Maatskaplike Werk, 2010 This paper provides a description of the psychosocial problems experienced by learners in threesecondary schools in the Western Cape. This research aimed at eliciting the personalexperiences of learners and then describing these data in comparison with ...
Philip Geldenhuys, Annemarie Youngleson
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Psychology Research and Behavior Management, 2023 Xinyi Dai, Shu Tang Faculty of Humanities and Social Sciences, Jinling Institute of Technology, Nanjing, 210038, People’s Republic of ChinaCorrespondence: Xinyi Dai, Email emma2242020@126.comBackground: Research on the restorative environment has long ...
Dai X, Tang S
doaj
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
A Study of Social Memory and Forgetting by Paul Connerton: Mechanisms and Tools
CхідThis research is dedicated to the phenomenon of social memory and its component, social amnesia, as revealed in the works of the British sociologist and philosopher Paul Connerton.
Tetiana Kuprii
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source