Results 81 to 90 of about 2,982,709 (316)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Time & Society, 2007 The article addresses the analysis of time images furnished by a qualitative research made in Spain on the relations of working time and family/personal time. The analysis focuses on three widespread time metaphors used in day-to-day speeches by social agents. The first one is the metaphor of time as resource for action. Its value is equally economical,
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Social Ontology: Time to Compute
Vestnik Tomskogo gosudarstvennogo universiteta. Filosofiya, sotsiologiya, politologiya, 2020 Discussions on the alleged methodological specificity of social knowledge are fueled to not the least extent by a kind of retarded position of the latter against technological advance-ments of natural and information science based on exact methods and formal or quantitative languages.
openaire +2 more sources
, 2016 Building on existing Australian social statistics, Australia’s Social Pulse measures changes over time in key social indicators across a range of domains.
Centre for Social Impact
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
If Only the French Republicans Had Known This: The Week as a Social Fact
Societies, 2013 During the French Revolution and inspired by the Enlightenment, an attempt was made to replace the Gregorian calendar (which was based on ‘irrational’ overlapping cycles linked to religious celebrations) by the Republican calendar (which was based on ...
Djiwo Weenas +4 more
doaj +1 more source
Social progress index 2015 [PDF]
, 2015 The Social Progress Index, first released in 2014 building on a beta version previewed in 2013, measures a comprehensive array of components of social and environmental performance and aggregates them into an overall framework.
Social Progress Imperative
core
Fall 2021: Struggles Bring Opportunity
, 2021 In the Fall 2021 issue of Advances in Social Work, we are pleased to present 16 full-length papers written by 30 authors from different regions of the U.S. including Puerto Rico as well as from Ghana. An underlying theme of many of these contributions is
Adamek, Margaret E.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source