Results 141 to 150 of about 11,662 (265)

"Do not act blind": findings from qualitative interviews with adolescents and adults living with a visual impairment or blindness. [PDF]

BMC Public Health
Milde N, Kessel L, Larsen AC, Larsen K.
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Short Self-Assessment Questionnaire for Parents with Young Children on Caregiver Strengths and Strains: Development and Psychometric Properties of the Balance Scale. [PDF]

J Pediatr Clin Pract
Beekman AM, Schreuder A, de Ru JCR, van Stel HF, Staal IIE.   +4 more
europepmc   +1 more source

Repairing the upbringing: Socialization and product repair behavior

With growing concerns over sustainability and waste generation both globally and in Den-mark, understanding consumer behavior in product repair is crucial. This study investigates in-house product repair behavior in Danish households, focusing on the motivations, and barriers of repairs re-lated to social upbringing.
Møller, Sophia Rytter, Schmidt, Kamilla Strand-Holm, Laursen, Linda Nhu   +2 more
openaire   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

"Because I said so." - Collection and evaluation of parenting phrases in German-speaking samples. [PDF]

PLoS One
Kljucak E, Alazza NN, Hemme P, Kulke L.
europepmc   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Behind the Scenes: Affiliate Stigma and Posttraumatic Distress Among Mothers of Children With Neuropsychiatric Disorders. [PDF]

Stress Health
Lahav Y, Shalev A.
europepmc   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Association Between Urban Upbringing and Cortical Gyrification in Persons with Schizophrenia. [PDF]

Indian J Psychol Med
Korann V, Thonse U, Jacob A, Devi P, Padmanabha A, Praharaj SK, Bharath RD, Kumar V, Varambally S, Venkatasubramanian G, Rao NP.   +10 more
europepmc   +1 more source