Results 41 to 50 of about 11,695,139 (299)

Estudio Longitudinal Social de Chile 2016-2022

open access: yes, 2023
ELSOC has been designed to evaluate how Chileans think, feel, and behave regarding a set of social issues related to conflict and social cohesion in Chile.
Reproducible Research, Centre for Social Conflict and Cohesion Studies COES
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Around the “social pedagogy” of Paul Natorp: Vladimir Dinze in the debates on national upbringing. Part 2 [PDF]

open access: yesКантовский сборник, 2018
Many scholars and practitioners in the sphere of the public education and upbringing in Russia addressed themselves to the philosophical-pedagogical ideas of German philosopher of Neo- Kantian movement Paul Natorp.
Dmitrieva N. A.
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Love as the Fundamental Dynamics of Family Upbringing according to Chiara Lubich. Selected Aspects

open access: yesPaedagogia Christiana, 2019
Civilisational progress and globalisation processes at the turn of the 20th and 21st centuries have changed the shape, function and role of family in social life, posing a threat to its stability.
Mariola Teresa Kozubek
doaj   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Blessed Edmund Bojanowski's (1814-1871) pedagogical thought and the concept of integral child development and protection

open access: yesRozprawy Społeczne, 2020
The article explores Edmund Bojanowski's idea of integral upbringing with its intrinsic idea of child protection. It is based on the analysis of creative thought and explorations of this 19th-century outstanding Polish social activist and thinker.
Andrzej Piotr Łuczyński
doaj   +1 more source

Family as a Primary Socialization in Preschool Children Upbringing

open access: yesBulletin of Science and Practice, 2021
This article examines the role of the family and its features in the process of socialization, also the main forms and functions (informative, mentor function, initiating and orienting function) of the family. Effective mechanisms of family social education of a child were described including the psychological climate of the family and its factors ...
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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