Results 101 to 110 of about 1,444,284 (300)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Impact of the Expected Utility and Experienced Utility Gap on Electric Vehicle Repurchase Intention in Jiangsu, China

World Electric Vehicle Journal
The global automotive industry’ s rapid transformation has led to electric vehicles (EVs) capturing a significant market share as a sustainable transportation option.
Xiao Zheng, Jiaxin Huang, Mengzhe Wang, Wenbo Li   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Not All Digital Innovation Is Equal: Instructional Alignment Differentiates Motivation and Instructional Expectations in Undergraduate Nursing Education

Education Sciences
Social media environments and meme-based communication are increasingly incorporated into nursing education, yet it remains unclear whether students respond uniformly to digitally embedded instructional strategies.
Raúl Quintana-Alonso, Lucía Carton Erlandsson, Alberto Melián Ortiz, Elena Chamorro Rebollo   +3 more
doaj   +1 more source

Demand pre-suppositions in Some Muslim Economists’ Views and Revising them (An Epistemological Analysis of Utility) [PDF]

پژوهشهای اقتصادی, 2008
This paper aims to study some Muslim economists’ views towards pre- suppositions of demand theory in economics, benefiting from the method of analyzing rational behaviors, as well as considering the epistemology of utility.
hasan Agha Nazari
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Purchase Intention Model of Generation Z to Enhance Awareness of Green Products Consumptions

Riset Akuntansi dan Keuangan Indonesia
The increased world population makes the carrying capacity of nature even heavier and leads to various environmental problems. Consumption of green products is one of the solutions to overcome environmental problems.
Shinta Permata Sari, Banu Witono, Fatwasari Soeratno Putri, Gehad Mohammed Sultan Saif   +3 more
doaj   +1 more source

Extending the original position : revisiting the Pattanaik critique of Vickrey/Harsanyi utilitarianism [PDF]

, 2013
Harsanyi's original position treats personal identity, upon which each individual's utility depends, as risky. Pattanaik's critique is related to the problem of scaling "state-dependent" von Neumann-Morgenstern utility when determining subjective ...
Hammond, Peter J.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source