Results 121 to 130 of about 19,273,452 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Competing Values Regarding Internet Use in “Free” Philippine Social Institutions

, 2011
Erwin A. Alampay, Joselito C. Olpoc, Regina M. Hechanova   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Editorial: Emotional and social value of organizations. [PDF]

Front Psychol, 2022
Barba-Sánchez V, Retolaza JL, San-José L, Zicari A.   +3 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Value Alignment of Social Media Ranking Algorithms [PDF]

Farnaz Jahanbakhsh, Dora Zhao, Tiziano Piccardi, Zachary Robertson, Ziv Epstein, Sanmi Koyejo, Michael S. Bernstein   +6 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Approaches to sustaining people–place bonds in conservation planning: from value-based, living heritage, to the glocal community

Built Heritage
This review paper explores approaches to sustaining the enduring connection between communities and heritage places in conservation planning. Amidst global overtourism, the gradual outmigration and sudden displacement of local communities from heritage ...
Yueyi Chen, Yi-Wen Wang
doaj   +1 more source

The Role of Social Value Orientation in Chinese Adolescents' Moral Emotion Attribution. [PDF]

Behav Sci (Basel), 2022
Li Z, Dong D, Qiao J.
europepmc   +1 more source

Gender Differences in Students' Value System, Engagement, Social Competence, and Cognitive Styles

, 2020
Mahboobeh Moosivand
openalex   +1 more source