Results 141 to 150 of about 6,843,118 (357)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Landscape forest cover and regional context shape the conservation value of shaded cocoa agroforests for bees and social wasps [PDF]

José Victor Alves Ferreira, Víctor Arroyo‐Rodríguez, José Carlos Morante‐Filho, Danielle Storck‐Tonon, Alexandre Somavilla, José Augusto dos Santos-Silva, Thiago Mahlmann, Marcio Luiz de Oliveira, Maíra Benchimol   +8 more
openalex   +1 more source

The Value of Using Big Data Technologies in Computational Social Science [PDF]

, 2014
Eugene Ch’ng
openalex   +1 more source

Seeing social enterprise through the theoretical conceptualisation of ethical capital [PDF]

, 2008
Objectives: Current conceptualisations of social enterprise fail to fully satisfy an understanding of the movement. A focus on the economic implies a business model where deep tensions lie. A focus on social capital offers a different frame of reference,
Bull, M., Foster, D., Ridley-Duff, R., Seanor, P.   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Approaches to sustaining people–place bonds in conservation planning: from value-based, living heritage, to the glocal community

Built Heritage
This review paper explores approaches to sustaining the enduring connection between communities and heritage places in conservation planning. Amidst global overtourism, the gradual outmigration and sudden displacement of local communities from heritage ...
Yueyi Chen, Yi-Wen Wang
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Impact of National Service Scheme (NSS) on Social Norms and Values of Higher Education Students [PDF]

SANJOY MUDI -, Tuhin Kumar Samanta
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source