Results 161 to 170 of about 6,843,118 (357)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Baby Box scheme in Scotland: A study of public attitudes and social value. [PDF]
Health Expect, 2022 Skea Z +5 more
europepmc +1 more source
Estimating the Social Value of Higher Education: Willingness to Pay for Community and Technical Colleges [PDF]
Much is known about private returns to education in the form of higher earnings. Less is known about social value, over and above the private, market value.
Blomquist, Glenn C. +4 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Estimating a social value set for EQ-5D-5L in Sweden. [PDF]
Health Qual Life Outcomes, 2022 Sun S +4 more
europepmc +1 more source
, 2016 One of the main goals on this document is for obtain a wise knowledge about the diverse impacts and support the decisions in the social politics; especially in the evaluation and assignation of resources to social invest in programs or units where counting with concepts and tools that let the measurement of social values, and their different dimensions.
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Estimating the social value of nature-based solutions in European cities. [PDF]
Sci Rep, 2022 Bockarjova M +3 more
europepmc +1 more source
The Value of Being Socially Responsible: A Primal-Dual Approach
, 2018 Daniela Puggioni, Spiro E. Stefanou
openalex +1 more source