Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
THE CONSTITUTION AS A SOCIAL VALUE AND SOCIAL VALUES IN THE CONSTITUTION
Abstract Modern jurisprudence views the Constitution not merely as a legal act, but as a fundamental axiological system where human dignity is recognized as the source of the constitutional order and the supreme value. The core values of the Constitution are structured into four groups: anthropocentric, socio-economic, socio-political, and spiritual ...
openaire +1 more source
Operative public values as a tool for healthcare decisions: the social value and clinical criteria of triage. [PDF]
Philos Ethics Humanit Med, 2022 Cordeiro-Rodrigues L.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Prefrontal-Amygdala Pathways for Object and Social Value Representation. [PDF]
J Cogn NeurosciPujara MS, Murray EA.
europepmc +1 more source
The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain. [PDF]
Front Public Health, 2023 Maravilla-Herrera P +14 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Reimagining Social Value to Consider the Environment: How Should We Judge the Magnitude of Benefits in Health Research? [PDF]
BioethicsPratt B, van der Graaf R.
europepmc +1 more source
Future of nature, our future. A preregistered report on future time perspective, social value orientation, and pro-environmental outcomes based on data from Poland and Sweden. [PDF]
Front Psychol, 2023 Nowakowska I, Rönnlund M.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source