Results 61 to 70 of about 142,651 (290)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Inspired to Lend a Hand? Attempts to Elicit Prosocial Behavior Through Goal Contagion
Frontiers in Psychology, 2019 Helping often occurs in a broader social context. Every day, people observe others who require help, but also others who provide help. Research on goal contagion suggests that observing other people’s goal-directed behavior (like helping) activates the ...
Hilmar Brohmer +6 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
European Journal of Personality, 2022 Nearly 25 years ago, four studies examined the development of social value orientation (SVO) and uncovered that SVO was related to specific and general adult attachment, the number of siblings, and age. However, some of these findings have been challenged by two recent replication studies. The present (pre-registered) research extends these replication
Yi Liu, Bo Wang, Paul A. M. Van Lange
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Cooperative preferences fluctuate across the menstrual cycle
Judgment and Decision Making, 2015 Social Value Orientation (SVO) refers to an individual’s preference for the division of resources between the self and another person. Since evidence suggests that hormones influence several facets of human social behavior, we asked whether SVO might ...
Christine Anderl +5 more
doaj +1 more source
Do multiple-trial games better reflect prosocial behavior than single-trial games?
Judgment and Decision Making, 2020 Most prior research on the external validity of mixed-motive games has studied only one single game version and/or one specific type of real-life prosocial behavior. The present study employs a different approach.
Tessa Haesevoets +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source