Results 51 to 60 of about 31,234 (305)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The Impact of Social Value Orientations on Negotiator Cognition and Behavior [PDF]

Personality and Social Psychology Bulletin, 1995
Prior research using experimental games has demonstrated that social value orientations affect the ways in which individuals approach and react to interdependent others; prosocials exhibit greater cooperation than individualists and competitors. This article extends these lines of research by examining the influence of social value orientations on ...
De Dreu, C.K.W., Van Lange, P.A.M.
openaire   +3 more sources

Social value orientation modulates behavioral and neural responses to social influence

Human Brain Mapping, 2023
AbstractSubstantial studies have investigated the social influence effect; however, how individuals with different social value orientations (SVOs), prosocials and proselfs, respond to different social influences remains unknown. This study examines the impact of positive and negative social information on the responses of people with different SVOs. A
Yanyan Qi, Zhihui Liu, Siqi Cao, Yixin Han, Qiong Wang, Xun Liu, Haiyan Wu   +6 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Car versus public transportation? The role of social value orientations in a real-life social dilemma

, 1995
This research evaluates the role of social value orientations (i.e., preferences for distribution of outcomes for the self and others) in decisions as how to commute.
Ree M. Meertens, Van Lange, Paul A.M., Van Vugt, Mark, Paul A. M. Van Lange, Meertens, Ree M., Van Lange, Paul A.M.; id_orcid, Mark Van Vugt   +6 more
core   +1 more source

Social value orientation as a moral intuition: Decision making in the dictator game. [PDF]

We studied the hypothesis that social value orientations are expressed automatically in behavior, as would be suggested by the social intuitionist model.
Cornelissen, Gert, Dewitte, Siegfried, Warlop, Luk   +2 more
core   +2 more sources

Axiological criteria for predicting the success of socio-psychological adaptation of schoolchildren of younger adolescence

Вестник Мининского университета
Introduction. The system of personal value orientations is considered the main determinant of the processes of socio-psychological adaptation. The value structure has a significant impact on both the development and formation of a personality, as well as
V. M. Golyanich, A. F. Bondaruk, M. V. Zagasheva   +2 more
doaj   +1 more source

The development of social value orientation: Attachment styles, number of siblings, age, and a comparison of measures

European Journal of Personality, 2022
Nearly 25 years ago, four studies examined the development of social value orientation (SVO) and uncovered that SVO was related to specific and general adult attachment, the number of siblings, and age. However, some of these findings have been challenged by two recent replication studies. The present (pre-registered) research extends these replication
Yi Liu, Bo Wang, Paul A. M. Van Lange
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source