Results 151 to 160 of about 1,605,555 (314)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of Social Values for Ecosystem Services in Urban Riverfront Space Based on the SolVES Model: A Case Study of the Fenghe River, Xi'an, China. [PDF]

Int J Environ Res Public Health, 2021
Zhang Z, Zhang H, Feng J, Wang Y, Liu K.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Social Values Reflections Through the Use of EFL Storytelling: An Action Research with Primary Students

HOW, 2013
This article reports on the results of an action research project carried out with a group of third graders at a public school in Bogotá. The project aimed to gain insights into the use of English as foreign language storytelling and to analyze the way ...
Claudia Milena Gómez Combariza, María Ximena Rodríguez Chapetón, Vanessa Alejandra Rojas Rincón   +2 more
doaj  

Relationships among social dominance orientation, social axioms, and values

, 2014
We adopted 2 cross-culturally validated instruments, developed for the measurement of human values (Schwartz's value model) and generalized beliefs (Leung and Bond's social axioms model), to examine their relationships with the perceptions of legitimacy,
Akoğlu, Selinay Çağlar
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Northern Ireland European Values Survey, 1999

, 2001
copyright UK Data Service and data collection copyright owner.The European Values Study (EVS) and World Values Survey (WVS) series is designed to enable a cross-national, cross-cultural comparison of values and norms on a wide variety of topics and to ...
Sinnott, R., University College Dublin, Centre for European Economic and Public Affairs, Fahey, T., Economic and Social Research Institute (Dublin), Hayes, B. C., Queen's University of Belfast, Department of Sociology and Social Policy   +2 more
core  

World Values Survey 2000: Finnish Data

, 2002
World Values Survey 2000: Suomen aineisto kartoittaa monipuolisesti suomalaisten arvomaailmaa, asenteita ja elämäntilannetta. Haastatelluilta kysyttiin eri elämänalueiden tärkeyttä (mm. perhe, työ, vapaa-aika).
Kirkon tutkimuskeskus, Gallup Finland, Suomen Gallup, Church Research Institute, World Values Study Group   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source