Results 41 to 50 of about 210,600 (312)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Social vulnerability to flood disasters in the nine provinces of the Yellow River Basin

open access: yesGuan'gai paishui xuebao
【Objective】The Yellow River Basin is prone to urban flood disasters. Social vulnerability assessment is thus crucial for optimizing disaster prevention and mitigation strategies and promoting harmonious coexistence of ‘people, city, and water’.
NIU Wenxuan, DONG Jiayi, XU Panpan
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

A vulnerabilidade social em tempos de acumulação flexível: uma contribuição para o debate no campo socioambiental

open access: yesDesenvolvimento e Meio Ambiente, 2016
The notion of vulnerability has been used in various fields of knowledge. One of its uses is in interdisciplinary research on environmental vulnerability, in which is understood in a simplified way as the overlap of social vulnerability and environmental
Natália Tavares Azevedo
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Study of Integrated Social Vulnerability Index SoVIint of Hilly Region of Uttarakhand, India

open access: yesEnvironmental and Climate Technologies, 2020
The hilly regions of India have suffered many disasters, both natural and anthropogenic. In the hilly state like Uttarakhand, the hazards like flash flood, forest fires, and landslide affect the community at the large scale.
Kumar Dilip, Kumar Bhattacharjya Rajib
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Exploitation, Vulnerability, and Social Domination

open access: yesPhilosophy & Public Affairs, 2013
This article attempts to revive a research program by criticizing it. Its object of criticism is the powerful research agenda of analytical Marxism. I shall attempt this revival by criticizing the views of two of the most influential members of that research program, G. A. Cohen and John Roemer.
openaire   +3 more sources

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