Results 61 to 70 of about 1,047,658 (304)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Two theoretical dimensions of the cyber hate crime [PDF]

open access: yes, 2017
The impact and relationship between technologies and society establish the development of certain adaptive models, based on coexistence (Human-information-Machine), as well as several behavioral and cognitive changes of the human being, and new models of
Salas, Cesar Rommel
core  

Interdisciplinary and team research [PDF]

open access: yes, 2020
As funds grow scarcer for research in Canada, the vulnerability of the social sciences and humanities to budget restrictions appears to be growing ever greater.
Ommer, Rosemary E.
core   +1 more source

Social Vulnerability and Touristification of Historic Centers [PDF]

open access: yes, 2019
Historic centers have su ered di erent processes of neglect, occupation, segregation, gentrification, and touristification as a result of changes in demand and policies.
Fernández Tabales, Alfonso   +2 more
core   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Exploitation, Vulnerability, and Social Domination

open access: yesPhilosophy & Public Affairs, 2013
This article attempts to revive a research program by criticizing it. Its object of criticism is the powerful research agenda of analytical Marxism. I shall attempt this revival by criticizing the views of two of the most influential members of that research program, G. A. Cohen and John Roemer.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

A theoretical and methodological essay on the concept of vulnerability / Un ensayo teórico y metodológico sobre el concepto de vulnerabilidad

open access: yesContexto: Revista de la Facultad de Arquitectura Universidad Autónoma de Nuevo León, 2018
This paper presents a bibliographical review on the concept and methods of identifying vulnerability in urban areas. From systematic bibliographic searches, the main concepts that orbit around vulnerability are defined, as well as their concretion ...
Antonio Palacios García   +2 more
doaj  

Spatial-Explicit Modeling of Social Vulnerability to Malaria in East Africa. [PDF]

open access: yes, 2014
Despite efforts in eradication and control, malaria remains a global challenge, particularly affecting vulnerable groups. Despite the recession in malaria cases, previously malaria free areas are increasingly confronted with epidemics as a result of ...
Hagenlocher, Michael, Kienberger, Stefan
core   +4 more sources

Home - About - Disclaimer - Privacy