Results 81 to 90 of about 8,864,416 (306)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Floods in the Urban Environment and Social Vulnerability: a study case in Curitiba, Brazil

Redes, 2019
This paper deals with the spatial relationship of social vulnerability and the flooding areas in the central portion of the Belem River Basin, in Curitiba / Brazil, as the research problem being the possible aggregation of aspects of environmental ...
Edilberto Nunes Moura, Ariadne Stradiotto Frenzel, Isabela Ignácio de Moura   +2 more
doaj   +1 more source

Analysis of Urban Sprawl Effects on Social Vulnerability (Case Study: Qazvin City Districts) [PDF]

توسعه پایدار شهری, 2021
Iran is an earthquake-prone country that many cities have experienced the earthquake. Magnitude of earthquake damage not only depends on physical destructions, but also one of the major dimensions of earthquake hazards is social vulnerability.In this ...
Esfandyar Zebardast, Hossein Ghanooni
doaj  

The utilization of physically based models and GIS techniques for comprehensive risk assessment of storm surge: A case study of Huizhou

Frontiers in Marine Science, 2022
Quantitative analyses of storm surge risk, which are mostly focused on physical vulnerability, have been widely used to help coastal communities mitigate impacts and damage.
Si Wang, Si Wang, Si Wang, Lin Mu, Lin Mu, Hao Qin, Lizhe Wang, Zhenfeng Yao, Enjin Zhao   +8 more
doaj   +1 more source

Unpacking Adaptive Capacity to Flooding in Urban Environments: Social Capital, Social Vulnerability, and Risk Perception

Frontiers in Water, 2021
To effectively cope with the impacts of climate change and increase urban resilience, households and neighborhoods must adapt in ways that reduce vulnerability to climate-related natural hazards. Communities in the United States and elsewhere are exposed
R. P. Bixler, Sandeep Paul, Jessica Jones, M. Preisser, P. Passalacqua   +4 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Social vulnerability assessment in the health and disease context: Review

Discover Social Science and Health
Background Social vulnerability is a multidimensional concept based on multivariate factors in domains of physical, social, economic, environmental, etc., and the subsets that constitute it.
Arya Mukkil Ashokan, Jegankumar Rajagopal, Prakash Krishnaswamy, Libina Rajendran Sheela, Prashanthi Devi Marimuthu, Dhanabalan Subbiah Pothumani   +5 more
doaj   +1 more source

Pharmacy Accessibility and Social Vulnerability

JAMA Network Open
This cross-sectional study examines the association of availability of primary care practitioners and level of socioeconomic vulnerability with risk of pharmacy deserts in regions of the US.
Catalano, Giovanni, Khan, Muhammad Muntazir Mehdi, Chatzipanagiotou, Odysseas P., Pawlik, Timothy M.   +3 more
openaire   +2 more sources

Preterm birth among pregnant women living in areas with high social vulnerability

American Journal of Obstetrics & Gynecology MFM, 2021
BACKGROUND: Communities and individuals widely vary in their resources and ability to respond to external stressors and insults. To identify vulnerable communities, the Centers for Disease Control and Prevention developed the Social Vulnerability Index ...
M. Givens, E. Teal, Varun Patel, T. Manuck   +3 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source