Results 81 to 90 of about 12,210,028 (311)

Does seasonal vulnerability to poverty matter? A case study from the Hadejia-Nguru Wetlands in Nigeria [PDF]

Applying research on vulnerability to seasonal data, we assess seasonal vulnerability to poverty using panel data from the Hadejia-Nguru Wetlands in Nigeria involving 260.
Waibel, Hermann, Chiwaula, Levison
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Lower social vulnerability is associated with a higher prevalence of social media-involved violent crimes in Prince George’s County, Maryland, 2018–2023

Injury Epidemiology
Background Social vulnerability may play a role in social media-involved crime, but few studies have investigated this issue. We investigated associations between social vulnerability and social media-involved violent crimes.
Jemar R. Bather, Diana Silver, Brendan P. Gill, Adrian Harris, Jin Yung Bae, Nina S. Parikh, Melody S. Goodman   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Infrastructure network vulnerability [PDF]

, 2011
The work presented in this paper aims to propose a methodology of analyzing infrastructure network vulnerability in the field of prevention or reduction of the natural disaster consequences.
Pérès, François, Kamissoko, Daouda, Zaraté, Pascale   +2 more
core  

Risk-based mapping of pesticide usage and social vulnerability in the contiguous United States

BMC Public Health
Background In the contiguous United States, environmental justice burdens and disparities in pesticide exposure are prevalent among racial and ethnic minorities and low socioeconomic groups.
Jabeen Taiba, Cheryl Beseler, Alan Kolok, Muhammad Zahid, Shannon Bartelt-Hunt, Eleanor Rogan   +5 more
doaj   +1 more source

Measuring social vulnerability to natural hazards at the district level in Botswana

Jàmbá, 2019
Social vulnerability to natural hazards has become a topical issue in the face of climate change. For disaster risk reduction strategies to be effective, prior assessments of social vulnerability have to be undertaken.
Kakanyo F. Dintwa, Gobopamang Letamo, Kennan Navaneetham   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mapping South African farming sector vulnerability to climate change and variability: A subnational assessment [PDF]

"This paper analyzes the vulnerability of South African farmers to climate change and variability by developing a vulnerability index and comparing vulnerability indicators across the nine provinces of the country.
Gbetibouo, Glwadys Aymone, Ringler, Claudia   +1 more
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source