Results 71 to 80 of about 12,210,028 (311)
Scientific ReportsInvestigating social vulnerability is a crucial aspect of attaining an in-depth understanding of disasters and disaster risk. This study developed a measurement framework for social vulnerability to geological disasters, obtained a comprehensive social ...
Yan Jia, Shuo Jia, Ruiqiu Pang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Trends in Economic Vulnerability in the Republic of Ireland [PDF]
In this paper we evaluate trends in levels of economic vulnerability in Ireland during the period 1994-2001. We also document changes in the consequences of such vulnerability for social exclusion and in the social demographic factors with which it is ...
Bertrand Maître +2 more
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Mapping socio-ecological vulnerability of tropical peatland fires
Environmental Research LettersPeatlands in Southeast Asia regularly experience fire due to clearance of forests and drainage for agriculture and plantation development. Fire represents a mainstay for rural communities managing tropical landscapes, but these can lead to uncontrolled ...
Janice Ser Huay Lee +8 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Vulnerability to Poverty in select Central Asian Countries [PDF]
In the extant literature either income or consumption expenditures as measured over short periods of time have been regarded as a proxy for the material well-being of households.
Tu Dang, Raghbendra Jha
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Societal Aspects of Vulnerability to Natural Hazards
Raumforschung und Raumordnung, 2012 To date, social vulnerability research has focused primarily on the individual and household levels, and on social institutions relevant to these two benchmarks.
Swen Zehetmair
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Measuring the Vulnerability of Subnational Regions [PDF]
A small but growing literature has been concerned about the economic (and environmental) vulnerability on the level of countries. Less attention is paid to the economic vulnerability of different regions within countries. By focusing on the vulnerability
Rossouw, Stephanie +2 more
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source