Results 51 to 60 of about 2,930,581 (344)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Tareas 2.0: la dimensión digital en el aula de español lengua extranjera [PDF]

marcoELE. Revista de Didáctica Español Lengua Extranjera, 2009
En este artículo los autores han buscado establecer una comparativa entre las características básicas de las nuevas aplicaciones de la web social y el proceso de enseñanza y aprendizaje de una segunda lengua, haciendo especial hincapié en las actitudes y
Herrera, Francisco, Conejo, Emilia
doaj  

Googling social interactions: web search engine based social network construction. [PDF]

PLoS ONE, 2010
Social network analysis has long been an untiring topic of sociology. However, until the era of information technology, the availability of data, mainly collected by the traditional method of personal survey, was highly limited and prevented large-scale ...
Sang Hoon Lee, Pan-Jun Kim, Yong-Yeol Ahn, Hawoong Jeong   +3 more
doaj   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Layered Label Propagation: A MultiResolution Coordinate-Free Ordering for Compressing Social Networks [PDF]

, 2011
We continue the line of research on graph compression started with WebGraph, but we move our focus to the compression of social networks in a proper sense (e.g., LiveJournal): the approaches that have been used for a long time to compress web graphs rely
Boldi, Paolo, Rosa, Marco, Santini, Massimo, Vigna, Sebastiano   +3 more
core   +3 more sources

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Associations Among Web-Based Civic Engagement and Discrimination, Web-Based Social Support, and Mental Health and Substance Use Risk Among LGBT Youth: Cross-Sectional Survey Study

Journal of Medical Internet Research, 2023
BackgroundSocial media use is ubiquitous among lesbian, gay, bisexual, and transgender or nonbinary (LGBT) adolescents. The time spent on LGBT sites and involvement in social justice–oriented web-based civic activities can ...
Xiangyu Tao, Celia Fisher
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

You never surf alone. Ubiquitous tracking of users' browsing habits [PDF]

, 2016
In the early age of the internet users enjoyed a large level of anonymity. At the time web pages were just hypertext documents; almost no personalisation of the user experience was o ered.
C Castelluccia, J Parra-Arnau, J Parra-Arnau, K Boda, K Michael, Lise Getoor, M Veeningen, Stuart Rose   +7 more
core   +3 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source