Results 71 to 80 of about 1,831,112 (242)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Effects of Aerobic Exercise on Body Image Attitudes in Women
Journal of Rehabilitation, 2010 Objective: Sociocultural emphasis and increased interest in physical attractiveness and current attitudes body structure have increased body image dissatisfaction among women.
Sareh Zar-Shenas +5 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ANALISIS PENGARUH GAYA KEPEMIMPINAN TERHADAP KINERJA PEGAWAI DI KANTOR SOSIAL DAN KESEJAHTERAAN RAKYAT KABUPATEN MALANG [PDF]
, 2007 Research is survey on the permanent employes in the social and people welfare office of malang regency entitled analysis on the effect of leadership style on Employees, performance in the social and people welfare office of malang regency.
MIATUN, MIATUN
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Measuring Social Welfare Gains in Social Assistance Programs: An Application to European Countries [PDF]
, 2019 This paper aims to provide a framework for a complete assessment of the overall welfare gains resulting from social assistance programs. We make use of a social welfare function that satisfies several properties that must be considered when measuring the
Ayala Cañón, Luis +1 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Extended paretian rules and relative utilitarianism [PDF]
, 1995 This paper introduces the 'Extended Pareto' axiom on Social welfare functions and gives a characterization of the axiom when it is assumed that the Social Welfare Functions that satisfy it in a framework of preferences over lotteries also satisfy the ...
Dhillon, Amrita
core +5 more sources
Physical Treatments, 2014 Purpose: Muscle activation of the proximal parts is necessary for distal activities. In fact, proximal muscles provide stabilized and controlled base for distal parts activities.
Nazanin Nakhaie +4 more
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