Results 61 to 70 of about 24,616,697 (377)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
European Perspectives on Social Work: Models of education and professional roles [PDF]
, 2009 Comparative research undertaken by the Thomas Coram Research Unit found that social workers in England have more responsibility and a wider remit than many of their continental European counterparts.
Boddy, Janet +2 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
International Journal of Educational Technology in Higher Education, 2021 Pedagogical foundations exist for incorporating technology in instruction; however, these foundations have not kept pace with technology's evolution.
Michael Lynch +3 more
doaj +1 more source
, 2020 It is often assumed that child care legislation is a response to scandals and inquiries from the 1948 Children Act to the Children Act 2004. This chapter looks in detail at the preparatory work preceding legislation and demonstrates that the impact of scandals has been greater on securing parliamentary time than it has in shaping legislation.
openaire +2 more sources
Integrated Primary Care and Social Work: A Systematic Review
Journal of the Society for Social Work and Research, 2018 Objective: Behavioral and physical health services are increasingly being integrated, with care provided by interprofessional teams of physicians, nurses, social workers, and other professionals.
M. Fraser +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Addressing homelessness among people with mental illness in Ghana: suggestions from Nsawam residents
Discover Public HealthHomelessness among people with mental illness is on the rise in many countries, including Ghana. To curb this phenomenon, appropriate measures must be taken by the relevant authorities.
George Ofosu Oti +4 more
doaj +1 more source
Interviewing as a Vehicle for Theoretical Sampling in Grounded Theory
International Journal of Qualitative Methods, 2021 Interviewing is a frequently deployed data collection method in grounded theory research. Theoretical sampling is a core feature of the grounded theory method. Theoretical sampling is commonly understood as a means for sampling participants with a set of
Geraldine Foley +3 more
doaj +1 more source