Results 61 to 70 of about 2,991,289 (316)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Addiction Science & Clinical PracticeBackground In the U.S. there are significant racial and gender disparities in the uptake of pre-exposure prophylaxis (PrEP). Black Americans represented 14% of PrEP users in 2022, but accounted for 42% of new HIV diagnoses in 2021 and in the South, Black
Dawn Goddard-Eckrich +12 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
VALUE BASED MANAGEMENT AT KELOMPOK USAHA BERSAMA (KUBE): English
Journal SampurasunJoint Business Group/Kelompok Usaha Bersama (KUBE) is a business scheme launched in 2010 by the Ministry of Social Affairs for underprivileged families who received social assistance from the Family Hope Program (PKH), with the idea that they will no ...
Yuce Sariningsih +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Social Inclusion, 2019 This article presents research on faith-based community organizing in the US to examine how congregation members engage in structural change efforts related to marginalized populations.
Sarah B. Garlington +3 more
doaj +1 more source
American Journal of Psychiatry, 1951 New schools for training occupational therapists are urgently needed in Canada (20). President Campbell of the Canadian Association for Occupational Therapy recommends undergraduate and graduate medical training in rehabilitation, establishment of professorial chairs in universities, provision of adequate training facilities, and the granting of ...
openaire +4 more sources
Between the acaderny and queerness : microaggressions in social work education
, 2017 Three emerging social work scholars share the results of an authoethnographic study exploring their experiences of microaggressions, related to sexual orientation, in social work academe.
Thompson, Michelle G. +2 more
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