Results 91 to 100 of about 5,272,410 (354)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Rancière and the poetics of the social sciences [PDF]

, 2009
This article reviews the significance of Jacques Rancière’s work for methodological debates in the social sciences, and education specifically. It explores the implications of framing methodology as an aesthetic endeavour, rather than as the applied ...
Pelletier, Caroline
core   +2 more sources

Retracing, Reimagining and Reconciling Our Roots in Social Work Education [PDF]

, 2023
Michele Sorensen, Valerie Triggs
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

What does transformation in Higher Education research culture look like? Evidence from action research within a diverse post-1992 department [version 2; peer review: 2 approved]

Routledge Open Research
Transforming research culture and environment has been a priority for UK Research and Innovation (UKRI) and has been reflected in recent rounds of the UK Research Excellence Framework (REF).
Ian Robson, Kirstin Mulholland, Chris Counihan, David Nichol, Carl Luke, William Gray, Arlene Anderson, Sophie Meller, Matthew Thomas Johnson, Jane Davies, Kay Heslop, Pamela Graham, Sophie Beth Johnson, Wallace Chan, Se Kwang Hwang, Karen Hudson, Elliott Johnson, David Littlefair, Catherine Haighton, Allan Kellehear, Greta Defeyter, Joanne Atkinson   +21 more
doaj   +1 more source

Methods of patriotic education in social work [PDF]

, 2012
Hasło w "Słowniku metod, technik i form pracy socjalnej, opiekuńczej i terapeutycznej" ukazuje zastosowanie metod wychowania patriotycznego w pracy socjalnej.The entry in "The dictionary of methods, techniques and forms in the social, caring and ...
Tytko, Marek Mariusz
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

What does transformation in Higher Education research culture look like? Evidence from action research within a diverse post-1992 department [version 1; peer review: 2 approved]

Routledge Open Research
Transforming research culture and environment has been a priority for UK Research and Innovation (UKRI) and has been reflected in recent rounds of the UK Research Excellence Framework (REF).
Ian Robson, Kirstin Mulholland, Chris Counihan, David Nichol, Carl Luke, William Gray, Arlene Anderson, Sophie Meller, Matthew Thomas Johnson, Jane Davies, Kay Heslop, Pamela Graham, Sophie Beth Johnson, Wallace Chan, Se Kwang Hwang, Karen Hudson, Elliott Johnson, David Littlefair, Catherine Haighton, Allan Kellehear, Greta Defeyter, Joanne Atkinson   +21 more
doaj   +1 more source