Results 81 to 90 of about 5,330,925 (307)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
HeliyonOver the last few decades, Information and Communication Technologies (ICT) have brought about significant disruptions across nearly every industry, including education.
Kateryna Ivanishchenko +2 more
doaj +1 more source
Social work education : critical imperatives for social change. [PDF]
, 2013 Hegemonic discourses and ideologies of social work in South Africa, arose from the racist capitalism of colonialism and apartheid. Imperatives for social justice and social change therefore require that social work education reflect on and develop ...
Harms Smith, Linda
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the edge of a new frontier: Is gerontological social work in the UK ready to meet twenty-first-century challenges? [PDF]
, 2013 This article is available open access through the publisher’s website. Copyright @ 2013 The Authors.This article explores the readiness of gerontological social work in the UK for meeting the challenges of an ageing society by investigating the focus on ...
A. Milne +13 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Campbell Systematic ReviewsBackground Investment in mobile devices to support primary or elementary education is increasing and must be informed by robust evidence to demonstrate impact.
Claire Dorris +3 more
doaj +1 more source
Outcomes of social work education: The case for social work self-efficacy [PDF]
, 2007 Has social work education been effective at promoting the development of specific practice skills and how can students’ skill levels feasibly be assessed?
Anastas, Jeane +3 more
core +1 more source
Rancière and the poetics of the social sciences [PDF]
, 2009 This article reviews the significance of Jacques Rancière’s work for methodological debates in the social sciences, and education specifically. It explores the implications of framing methodology as an aesthetic endeavour, rather than as the applied ...
Pelletier, Caroline
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source