Results 91 to 100 of about 236,324 (311)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Negotiating the Path of Ethical Decision-Making in Health Care Social Work

open access: yesCritical Social Work, 2019
Understanding ethical decision-making in the context of “end of life” and other health care situations is examined using a model, which describes the process of decision-making and the influences of resources, knowledge, values, responsibility and the ...
Beverlee McIntosh, Ralph Vander Hoek
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Combatting human trafficking as an Advanced Generalist social worker

open access: yes, 2014
Drawing upon personal, professional, and academic expertise in the areas of runaway, homeless, and street youth, as well as domestic sex trafficking, the author of this article provides readers with a raw and transparent look into to how she, as an ...
Countryman-Roswurm, Karen I.
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

ON THE MACROECONOMIC CONSEQUENCES OF WORKER CONTROL ON WAGES AND EMPLOYMENT

open access: yes, 2015
The standard explanation of wage rigidity in principal agent and in efficiency wage models is related to worker risk aversion. However, these explanations does not consider at least two important classes of empirical evidence: (1) In worker cooperatives ...
CECILIA NAVARRA   +2 more
core  

Collaboration in the return-to-work process after sick leave due to common mental disorders: a qualitative study of stakeholders’ views on goals and roles

open access: yesBMC Public Health
Background This study explores how the goals of collaboration in the return-to-work (RTW) process for people with common mental disorders are described by the stakeholders involved, and how they experience stakeholders’ roles and responsibilities in ...
Veronica Svärd   +5 more
doaj   +1 more source

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