Results 71 to 80 of about 1,240,631 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Putting Women's Health Care Disparities on the Map: Examining Racial and Ethnic Disparities at the State Level [PDF]

open access: yes, 2009
Assesses the racial/ethnic disparities in women's health status, access to and utilization of health care, and social factors such as poverty and gender wage gap by state.
Alina Salganicoff   +5 more
core  

Fixed laws, fluid lives: the citizenship status of post-retirement migrants in the European Union [PDF]

open access: yes, 2004
This paper presents key findings of a recently completed socio-legal study of international retirement migration in the European Union (EU).1 It highlights the diverse nature of retirement migration and the differential citizenship status that is ...
Ackers, L, Dwyer, PJ
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Quality of Life of People Living with Cancer Under Institutionalized Palliative Care and Community Based Palliative Care in Kerala​

open access: yesJournal of Social Work Education and Practice, 2023
This study compares the Quality of Life (QoL) of Cancer Patients under Institutionalized Palliative Care (IPC) and Community Based Palliative Care (CBPC) in Kerala.  A Comparative and descriptive research designed was adopted for the study. The universe
Kiirii Aniljoy, Jona V
doaj   +2 more sources

Transforming Settlement Work

open access: yesCritical Social Work, 2019
Today, the concept of anti-oppression is prevalent in social work education, research, policy, and practice. However, it is a relatively new concept in the settlement sector, and little is known about its application in settlement work.
Jennifer Clarke, Eileen Wan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Social Incentives in the Workplace [PDF]

open access: yes, 2007
We present evidence on social incentives in the workplace, namely on whether workers' behaviour is affected by the presence of those they are socially tied to, even in settings where there are no externalities among workers due to either the production ...
Bandiera, O, Barankay, I, Rasul, I
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy