Results 101 to 110 of about 2,737,336 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Raising the Social Security Payroll Tax Cap: How Many Workers Would Pay More? [PDF]

open access: yes, 2013
On January 1, the maximum amount of annual earnings subject to the Social Security tax -- a.k.a. the payroll tax cap -- increased to $113,700. Every year, this cap is adjusted to keep up with inflation.
Janelle Jones, John Schmitt, Nicole Woo
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Work-Life Balance, Work Addiction and Job Satisfaction of Professional Social Workers in Kerala

open access: yesJournal of Social Work Education and Practice, 2023
Social work is a profession that aims to improve people's quality of life. The discipline focuses on assisting those experiencing difficulties and troubles in finding solutions and helping themselves.
Sona Francis, Cyril John, Selgin Joseph
doaj  

When a Parent Is Incarcerated: A Primer for Social Workers [PDF]

open access: yes, 2011
Offers guidance on meeting the needs of children of incarcerated parents, including reducing trauma, engaging incarcerated parents, re-entry planning, addressing domestic violence, and issues for parents in deportation proceedings.
Ken Borelli, Yali Lincroft
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

‘Rogue’ Social Workers: The Problem with Rules for Ethical Behaviour [PDF]

open access: yes, 2014
This article explores one aspect of increased managerialism, the impact of the expansion of rules in organizations. Discussing findings from a recent large-scale Canadian research project with social workers, this paper addresses some of the effects of ...
Taylor, Stephanie, Weinberg, Merlinda
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Social Security: The Trust Fund [PDF]

open access: yes, 2013
The Social Security program pays benefits to retired or disabled workers and their family members, and to family members of deceased workers. Program income and outgo are accounted for in two separate trust funds authorized under Title II of the Social ...
Nuschler, Dawn, Sidor, Gary
core   +2 more sources

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