Results 101 to 110 of about 2,765,395 (317)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Scarring, Habituation and Social Exclusion: Work Histories in Secure and Insecure Employment [PDF]

open access: yes
This paper analyses the impact of unemployment experiences on the life satisfaction of Australian workers in casual and permanent employment. Using panel data techniques, it was found that male permanent workers were scarred by previous unemployment ...
Colin P. Green, Gareth D. Leeves
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The Development of the Social Protection System in the Context of Improving the Legal and Economic Status of Public Organizations in the Russian Federation

open access: yesAstra Salvensis, 2019
Currently in the Russian Federation more than thirty million people use various services of state social organizations. The main categories of recipients of social services are persons with disabilities, elderly citizens, orphans and children left ...
Oksana Viktorovna NIKONOVA
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Jay, Maine, Fights for Jobs and the Environment [PDF]

open access: yes, 1994
[Excerpt] Since 1937, a social contract existed between International Paper and the paper-mill unions. This social contract is referred to locally as The Smell of Money : IP pays high wages, and workers and their families don\u27t complain about the ...
Kellman, Peter
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Insights from a retrospective study: an understanding of pediatric colorectal carcinoma

open access: yesEgyptian Pediatric Association Gazette
Pediatric colorectal cancer, comprising just 1% of childhood cancers, has surged among young individuals, underscoring its significant health impact. Diagnostic challenges arise from atypical presentation and nonspecific symptoms in 90% of cases, leading
Sofia Brenes Guzmán   +7 more
doaj   +1 more source

Railroad Retirement Board: Retirement, Survivor, Disability, Unemployment, and Sickness Benefits [PDF]

open access: yes, 2019
[Excerpt] The Railroad Retirement Board (RRB), an independent federal agency, administers retirement, survivor, disability, unemployment, and sickness insurance for railroad workers and their families under the Railroad Retirement Act (RRA) and Railroad ...
Li, Zhe
core   +1 more source

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