Results 81 to 90 of about 2,737,336 (312)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Role of Information for Retirement Behavior: Evidence based on the Stepwise Introduction of the Social Security Statement [PDF]
In 1995, the Social Security Administration started sending out the annual Social Security Statement. It contains information about the worker's estimated benefits at the ages 62, 65, and 70. I use this unique natural experiment to analyze the retirement
Giovanni Mastrobuoni
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Street-Level Workers’ Discretion in the Changing Welfare
Cambio, 2019 A crisis and deep re-organisation of European welfare systems started in the 1970s. Both the demand for and supply of welfare intervention are involved in relevant transformations, and the street-level workers are placed right at the crucial point where ...
Tatiana Saruis
doaj +1 more source
The Social Security Retirement Age: In Brief [PDF]
, 2015 [Excerpt] Two important ages may affect a worker’s decision of when to claim Social Security retired-worker benefits. Workers may claim full Social Security benefits at the full retirement age (FRA), which is currently 66 and is rising gradually to the ...
Sidor, Gary
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
The Modified Pharaoh Approach: Stingless bees mummify beetle parasites alive [PDF]
, 2008 Social insect colonies usually live in nests, which are often invaded by parasitic species^1^. Workers from these colonies use different defence strategies to combat invaders^1^.
Anne Dollin +6 more
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Astra Salvensis, 2019 Currently in the Russian Federation more than thirty million people use various services of state social organizations. The main categories of recipients of social services are persons with disabilities, elderly citizens, orphans and children left ...
Oksana Viktorovna NIKONOVA
doaj