Results 61 to 70 of about 2,210,793 (307)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Immigrant Labor and the Issue of “Dirty Work” in Advanced Industrial Societies [PDF]
, 1993 [Excerpt] Of the multiple explanations for the post-World War II immigration experiences of those advanced industrial nations where the phenomena occurred, the most pernicious has been that immigrants are needed to do the dirty work.
Briggs, Vernon M
core +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
In Defense of a Category-Based System for Unification Admissions [PDF]
, 2018 Liberal societies typically prefer relatives and spouses of their members over other prospective immigrants seeking admission. Giving this preferential treatment to only certain categories of relationships requires justification. In this paper, I provide
Lindauer, Matthew
core +2 more sources
, 2016 This essay surveys the long-term negotiation of religious reform in European villages. Following an account of institutional developments and popular religion in late medieval parishes, it traces the—selective—reception of the Lutheran, Zwinglian, and Calvinist messages, especially in the Holy Roman Empire, Scandinavia, the British Isles, Eastern ...
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Voting for Committees in Agreeable Societies
, 2014 We examine the following voting situation. A committee of $k$ people is to be formed from a pool of n candidates. The voters selecting the committee will submit a list of $j$ candidates that they would prefer to be on the committee.
Davis, Matt +2 more
core +1 more source
Social conformity and bounded rationality in arbitrary games with incomplete information: some first results [PDF]
, 2003 Intepret a set of players all playing the same pure strategy and all with similar attributes as a society. Is it consistent with self interested behaviour for a population to organise itself into a relatively small number of societies? By introducing the
Cartwright, Edward, Wooders, Myrna Holtz
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source