Results 61 to 70 of about 18,424,379 (354)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The Artscience of Planet Formation Import ArtScience.PlanetFormation as AATS

open access: yesPoiésis, 2019
The Art, Astronomy, Technology and Society (AATS) project is an artscience collaboration which dwells in the inbetweenness layer of scientific understanding of the origins of planets and the embodied, intuited ways of knowing.
Sebástian Pérez
doaj   +1 more source

Sports, Inc. Volume 9, Issue 2 [PDF]

open access: yes, 2017
The ILR Cornell Sports Business Society magazine is a semester publication titled Sports, Inc. This publication serves as a space for our membership to publish and feature in-depth research and well-thought out ideas to advance the world of sport.
ILR Cornell Sports Business Society
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Clinical Practice Guidelines for ERAS in China(2021)(Ⅳ)

open access: yesXiehe Yixue Zazhi, 2021
Chinese Society of Surgery   +1 more
doaj   +1 more source

O INDIVÍDUO E A SOCIEDADE PARA ALÉM DAS PARTES E DO TODO: UMA LEITURA PSICANALÍTICA E FILOSÓFICA

open access: yesLexCult, 2020
his article aims to carry out a transdisciplinary ontological reflection, starting from epistemological principles of philosophy, sociology and psychoanalysis, on the relationship between subject and society.
Mariana Monteiro   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Clinical Practice Guidelines for ERAS in China(2021)(Ⅴ)

open access: yesXiehe Yixue Zazhi, 2021
Chinese Society of Surgery   +1 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Clinical Practice Guidelines for ERAS in China(2021)(Ⅲ)

open access: yesXiehe Yixue Zazhi, 2021
Chinese Society of Surgery   +1 more
doaj   +1 more source

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