Results 101 to 110 of about 85,285 (279)

Lactate Regulates Metabolic and Proinflammatory Circuits in Control of T Cell Migration and Effector Functions [PDF]

, 2015
Licensed by the Creative Commons Attribution ...
A Ene-Obong, A Lardner, AM Sidahmed, C Croia, C Gobelet, C Mauro, C Nathan, CH Chang, Claudio Mauro, Costantino Pitzalis, DK Finlay, DR Wahl, DW Jung, Elliot J. Bland, F Humby, F Vegran, Federica M. Marelli-Berg, Fulvio D’Acquisto, FW Fitch, G Yi, J Olloquequi, J Zhu, Joanne Smith, JR Doherty, K De Bock, K Fischer, KJ Livak, LZ Shi, M Buzzai, M Chabaud, M Kleinewietfeld, M Sukumar, Mauro Perretti, ME Morris, Michele Bombardieri, MJ Ovens, MM Delmastro-Greenwood, N Shyh-Chang, O Haworth, OR Colegio, Philippa Marrack, PP Hsu, R Haas, R Wang, RA Robergs, RD Michalek, Robert Haas, S Su, SJ Jarmin, SN Mueller, SP Young, SR Srinivas, SS Metkar, Suchita Nadkarni, T Hashimoto, T Hitosugi, T Montero-Melendez, T Soga, TC Leite, Trinidad Montero-Melendez, VA Gerriets, Vidalba Rocher-Ros, Y Cao   +62 more
core   +5 more sources

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Effects of the sodium–glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b–4 chronic kidney disease [PDF]

, 2017
BACKGROUND: The sodium–glucose co-transporter 2 inhibitor dapagliflozin decreases haemoglobin A1c (HbA1c), body weight, blood pressure (BP) and urinary albumin:creatinine ratio (UACR) in patients with type 2 diabetes.
Cain, V, Dekkers, CCJ, Heerspink, HJL, Sjostrom, CD, Stefansson, BV, Wheeler, DC   +5 more
core   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source

Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. [PDF]

, 2018
A novel glucose transporter, the sodium glucose cotransporter 2 (SGLT2), has been demonstrated to contribute to the demand for glucose by pancreatic and prostate tumors, and its functional activity has been imaged using a SGLT specific PET imaging probe,
Barrio, Jorge R, Bergsneider, Marvin, Huang, Sung-Cheng, Kepe, Vladimir, Liu, Jie, Scafoglio, Claudio, Wright, Ernest M, Yong, William H   +7 more
core   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death. [PDF]

, 2019
学位記番号 ...
Shibusawa, Ryo, シブサワ, リョウ, 澁澤, 良   +2 more
core  

Baseline characteristics and enrichment results from the SONAR trial [PDF]

, 2018
Aim: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in the urinary albumin‐to‐creatinine ratio [UACR]) and safety/
Andress, Dennis L., Bakris, George, Brennan, John J., Correa-Rotter, Ricardo, de Zeeuw, Dick, Heerspink, Hiddo J.L., Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John, Parving, Hans-Henrik, Perkovic, Vlado, Tobe, Sheldon, Wigderson, Melissa, Yi, Tingting   +15 more
core   +3 more sources