Results 231 to 240 of about 29,662,154 (279)

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Sodium-glucose co-transporter 2 inhibitors: a pleiotropic drug in humans with promising results in cats. [PDF]

Front Vet Sci
Vieira AB, Cavanaugh SM, Ciambarella BT, Machado MV.   +3 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Safety and Effectiveness of Sodium-Glucose Co-Transporter 2 Inhibitors in Active Cancer Patients with Heart Failure: Results of the Observational TOSCA Trial. [PDF]

J Cardiovasc Dev Dis
Canale ML, Fabiani I, Delle Donne MG, Chianca M, Barletta V, Capati E, Solinas M, Frediani L, Venturini E, Arena G, Zucchelli G, Pasanisi EM, Amoroso D, Allegrini G, De Caterina R, Emdin M, Camerini A.   +16 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Methodological and Statistical Concerns Regarding "Can Sodium-Glucose Co-Transporter-2 Inhibitors Improve Sleep Quality, Anxiety, and Quality of Life in Patients With Heart Failure?" [PDF]

Clin Cardiol
Gupta R, Vohra S, Yadav A, Gupta N, Mody R.   +4 more
europepmc   +1 more source

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

Localization of the therapeutic targets for endothelin receptor antagonists and sodium-glucose co-transporter 2 inhibitors in the chronic liver disease, primary sclerosing cholangitis. [PDF]

Front Pharmacol
Kuc RE, Paterson AL, Williams TL, Gelson WTH, Greasley PJ, Ambery P, Maguire JJ, Davenport AP.   +7 more
europepmc   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

Angewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee, Letizia Dondi, Amal Mathai, Connor Nurmi, Yingfu Li   +4 more
wiley   +1 more source

Effects of Sodium Glucose Co-Transporter 2 Inhibitors on Atrial Fibrillation Recurrences After Catheter Ablation in Atrial Fibrillation Patients: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Parsi S, Sonavane K, Ravi U, Shirsat PD, Chamarthi VS, Gabr M, Ponnam HC, Surani S, Bansal V, Kashyap R.   +9 more
europepmc   +1 more source