Results 81 to 90 of about 85,285 (279)

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Sodium-Glucose Co-Transporter-2 Inhibitors in Type 1 Diabetes: A Scoping Review

Hormone Research in Paediatrics, 2022
<b><i>Background:</i></b> With recent developments in diabetes technology, attaining adequate glucose control is more achievable than ever. Despite these improvements, a significant proportion of individuals with type 1 diabetes do not reach recommended glycaemic goals.
Tim Hropot, Tadej Battelino, Klemen Dovc
openaire   +3 more sources

Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis [PDF]

, 2016
Sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are a novel drug class for the treatment of diabetes. We aimed at describing the maximal benefits and risks associated with SGLT2-i for patients with type 2 diabetes.Systematic review and meta-analysis.
A Berhan, A Lewin, A Liakos, A Patel, AK Singh, B Bode, B Bode, B Neal, B Zinman, C Mathieu, C Sonesson, C Triplitt, Cathy Bennett, CJ Bailey, CJ Bailey, CJ Bailey, CS Kovacs, CS Kovacs, D Moher, D Vasilakou, DS Shyangdan, E Ferrannini, E Ferrannini, E Ferrannini, E Ferrannini, E Ferrannini, F Zaccardi, Filip K. Knop, FJ Lavalle-Gonzalez, G Guyatt, G Musso, G Schernthaner, H Liu, H Storgaard, H Storgaard, Heidi Storgaard, HJ Lambers Heerspink, HU Haering, HU Haring, HU Haring, IM Stratton, J Bolinder, J Bolinder, J Rosenstock, J Rosenstock, J Rosenstock, J Rosenstock, J Rosenstock, J Rosenstock, J Yoon, JF List, JH Wu, JP Wilding, JP Wilding, JP Wilding, JP Wilding, K Damman, K Kaku, K Kaku, K Stenlof, K Stenlof, K Strojek, K Strojek, L Ji, L Merker, LA Leiter, LA Leiter, LA Leiter, Lise L. Gluud, M Laakso, M Ridderstrale, M Ridderstråle, M Roden, M Sarnak, MA Nauck, MA Nauck, Magnus F. Grøndahl, MH Ahmed, Mikkel B. Christensen, N Inagaki, Noel Christopher Barengo, O Ljunggren, P Gaede, P Jose, RA DeFronzo, RR Henry, RR Holman, S Del Prato, S Goring, S Kalra, S Matthaei, S Matthaei, S Ross, SA Jabbour, SE Inzucchi, SE Kahn, T Forst, T Kadowaki, Tina Vilsbøll, W Duckworth, WL Baker, WT Cefalu, WT Cefalu, Y Yilmaz   +103 more
core   +3 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

ASSESSMENT OF SODIUM-GLUCOSE CO-TRANSPORTER INHIBITOR IN COMBINATION WITH INSULIN ON METABOLIC PARAMETERS AND RENAL MORPHOFUNCTIONAL CHANGES IN RATS WITH EXPERIMENTAL DIABETES MELLITUS

Juvenis Scientia, 2017
Sodium-glucose co-transporter type 2 inhibitors belong to modern class of oral hypoglycemic drugs, exerting its effect through the reduction of renal glucose reabsorption.
D. A. Lebedev, N. P. Likhonosov, Т. P. Tuchina, V. K. Bayrasheva, A. Yu. Babenko   +4 more
doaj  

Canagliflozin: A Review in Type 2 Diabetes. [PDF]

, 2017
peer reviewedCanagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D).
Deeks, Emma D., Scheen, André
core   +2 more sources

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives

Cardiovascular Diabetology, 2019
Sotagliflozin is a dual sodium–glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D). Sotagliflozin inhibits renal sodium–glucose co-transporter 2 (determining significant excretion of glucose
Chiara Maria Assunta Cefalo, Francesca Cinti, Simona Moffa, Flavia Impronta, Gian Pio Sorice, Teresa Mezza, Alfredo Pontecorvi, Andrea Giaccari   +7 more
doaj   +1 more source

Sodium-glucose co-transporter 2 (SGLT2) inhibitors

, 2020
peer ...
Mifsud, Simon, Schembri, Emma Louise, Montebello, Annalisa, Gruppetta, Mark   +3 more
openaire   +1 more source

Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]

, 2018
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core   +2 more sources