Results 71 to 80 of about 80,161 (286)

The role of sodium-glucose co-transporter-2 inhibitors in frail older adults with or without type 2 diabetes mellitus

Age and Ageing, 2022
Sodium-glucose co-transporter-2 (SGLT2) inhibitors offer significant outcome benefits beyond glucose lowering, including reduced risk of cardiovascular death, all-cause mortality, major adverse cardiovascular events, hospitalisations for heart failure ...
M. Evans, A. Morgan, Sarah Davies, H. Beba, W. Strain   +4 more
semanticscholar   +1 more source

Effect of Sodium-Glucose Cotransporter 2 Inhibitors on Weight Reduction in Overweight and Obese Populations without Diabetes: A Systematic Review and a Meta-Analysis

Journal of Obesity & Metabolic Syndrome, 2021
Background : We aimed to evaluate the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors for managing obesity in non-diabetic overweight or obese patients.
Yun Kyung Cho, Ye-Jee Kim, Chang Hee Jung   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

SGLT-2 Inhibitors and Renal Outcomes in Non-Diabetic Patients: A Systematic Review

Revista Portuguesa de Nefrologia e Hipertensão, 2023
Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown positive renal outcomes in diabetic patients. There is also emerging evidence in non-diabetic patients.
Mariana Silva de Sousa, Cristiana Maia de Almeida, Natália Marchão, Iolanda Godinho, José António Lopes, Joana Gameiro   +5 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Incidental diagnosis of euglycaemic diabetic ketoacidosis: a case report

Journal of the Pakistan Medical Association
Euglycaemic diabetic ketoacidosis (eu-DKA) is a rare but serious complication of sodium-glucose co-transporter 2 (SGLT2) inhibitors, characterized by metabolic acidosis, elevated ketones and may be overlooked because of the absence of marked ...
Abrar Ali, Salva Shariq, Ramsha Abid, Muhammad Qamar Masood   +3 more
doaj   +1 more source

Efficacy of sodium-glucose co-transporter-2 inhibitors in patients with heart failure

Российский кардиологический журнал, 2021
The article analyzes the new results of randomized clinical trials on the use of sodium-glucose co-transporter-2 inhibitors in patients with cardiovascular diseases, heart failure with and without type 2 diabetes.
E. V. Kovalenko, M. V. Lozhkina, G. G. Arabidze, V. G. Kryakushkin   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The Role of Sodium-Glucose Co-Transporter-2 Inhibitors on Diuretic Resistance in Heart Failure

International Journal of Molecular Sciences
Heart failure (HF) remains a major cause of morbidity and mortality worldwide. Recently, significant advances have been made in its treatment; however, diuretics remain the cornerstone in managing congestion in HF.
P. Stachteas, A. Nasoufidou, D. Patoulias, P. Karakasis, E. Karagiannidis, Michail-Angelos Mourtzos, A. Samaras, Xanthi Apostolidou, N. Fragakis   +8 more
semanticscholar   +1 more source

Adverse events associated with sodium glucose co-transporter 2 inhibitors: an overview of quantitative systematic reviews

Therapeutic Advances in Drug Safety, 2021
Background: Multiple published quantitative systematic reviews have reported on adverse events associated with the use of sodium glucose co-transporter 2 (SGLT-2) inhibitors in patients with type 2 diabetes mellitus.
Ryan Pelletier, K. Ng, Wajd Alkabbani, Youssef Labib, Nicolas Mourad, J. Gamble   +5 more
semanticscholar   +1 more source