Results 51 to 60 of about 1,648 (134)
CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1 [PDF]
, 2018 Na+-coupled acid–base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na+-coupled acid–base transporters are not available.
Kirill Tsirulnikov +32 more
core +1 more source
, 2022 In search for novel antibacterial compounds, bacterial sialic acid uptake inhibition represents a promising strategy. Sialic acid plays a critical role for growth and colonisation of several pathogenic bacteria, and its uptake inhibition in bacteria was ...
Bozzola, Tiago +12 more
core +1 more source
GeoHealth, Volume 9, Issue 2, February 2025.Abstract The challenges of human space exploration produce some of humanity's greatest technological and scientific advances, not excluding innovations in medicine. The microgravity environment causes a host of physiological changes, and exposure to dust on the Moon caused considerable pulmonary distress to astronauts during the Apollo missions. As the
Justin L. Wang +7 more
wiley +1 more source
Biology of Human Sodium Glucose Transporters
, 2011 There are two classes of glucose transporters involved in glucose homeostasis in the body, the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters (SGLTs).
Ernest M. Wright +2 more
core +1 more source
Transporter oligomerisation: roles in structure and function [PDF]
, 2018 Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features ...
Byrne, Bernadette +2 more
core +1 more source
Uniport, Not Proton-Symport, in a Non-Mammalian SLC23 Transporter.
, 2022 SLC23 family members are transporters of either nucleobases or ascorbate. While the mammalian SLC23 ascorbate transporters are sodium-coupled, the non-mammalian nucleobase transporters have been proposed, but not formally shown, to be proton-coupled ...
Holzhüter, K., Geertsma, E.
core +1 more source
The SLC6/NSS family members KAAT1 and CAATCH1 have weak chloride dependence
, 2008 KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta.(1,2) They are members of the SLC6/NSS family, which groups membrane proteins that use Na+, K+ and Cl- gradients for the coupled transport of amines ...
S. Bettè +4 more
core +1 more source
Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation
, 2021 HKT channels are a plant protein family involved in sodium (Na+) and potassium (K+) uptake and Na+-K+ homeostasis. Some HKTs underlie salt tolerance responses in plants, while others provide a mechanism to cope with short-term K+ shortage by allowing ...
Miguel A. Piñeros +5 more
core +1 more source
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. [PDF]
, 2018 Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes.
Grabe, Michael +10 more
core +1 more source