Results 101 to 110 of about 848,473 (279)
Advanced Science, EarlyView.A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann +7 more
wiley +1 more source
BMJ Open QualityAdvanced chronic kidney disease (CKD) is commonly associated with disturbances in acid-base balance. Studies have shown that correcting metabolic acidosis in CKD offers several clinical benefits, including slower disease progression and reduced mortality.
Jyoti Baharani, Laura Desai
doaj +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions
Advanced Science, EarlyView.This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu +12 more
wiley +1 more source
Effects of sodium bicarbonate ingestion on prolonged intermittent exercise
, 2003 The aim of this study was to determine the effects of sodium bicarbonate ingestion on prolonged intermittent exercise and ...
Moss, Paul; id_orcid +7 more
core +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Relationship between sodium and bicarbonate transport in the rat proximal convoluted tubule
, 1981 The relationship between net sodium and bicarbonate transport was studied by microperfusion of proximal convoluted tubules and peritubular capillaries. Bicarbonate absorption was unchanged as long as the sodium concentration remained above 40 meq/liter,
Y. L. Chan, G. Giebisch
core +1 more source
Soil pH Amelioration Synergizes Carbon Accrual with Yield Gains Under Organic Substitution
Advanced Science, EarlyView.Soil pH shifts towards neutrality in both acidic and alkaline soils under organic substitution. A global synthesis links pH amelioration to soil organic carbon accrual through enhanced microbial biomass after accounting for added organic carbon and its interaction with pH. This pH amelioration‐shared soil organic carbon accrual accounts for 5.1–8.6% of
Xunzhuo Dong +7 more
wiley +1 more source
Sodium bicarbonate for metabolic acidosis
Purpose of review The purpose of this review is to discuss the consequences of severe metabolic acidosis on organ function, examine the physiological controversies surrounding pH correction with sodium bicarbonate,
Boris Jung, Ary Serpa Neto, Tomoko Fujii
core +1 more source