Results 101 to 110 of about 14,459 (216)

Evaluating the effects of caffeine and sodium bicarbonate, ingested individually or in combination, and a taste-matched placebo on high-intensity cycling capacity in healthy males [PDF]

, 2015
This study evaluated the effects of ingesting sodium bicarbonate (NaHCO3) or caffeine individually or in combination on high-intensity cycling capacity.
Price, Mike J, Wilson, Susie, Tallis, Jason; id_orcid, Price, Mike J., Duncan, Mike, Hill, Cameron, Higgins, Matthew F, Duncan, Michael J.; id_orcid, Higgins, Matthew F., Duncan, Michael J., Higgins, M. F., Price, Michael J., Tallis, Jason   +12 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Optimising acid-base balance in patients with advanced chronic kidney disease: a quality improvement initiative

BMJ Open Quality
Advanced chronic kidney disease (CKD) is commonly associated with disturbances in acid-base balance. Studies have shown that correcting metabolic acidosis in CKD offers several clinical benefits, including slower disease progression and reduced mortality.
Jyoti Baharani, Laura Desai
doaj   +1 more source

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

Advanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui, Daxiang Cui   +10 more
wiley   +1 more source

Compounded medicines: tailored solution for rare diseases – the case of Urea Cycle Disorders and Primary Distal Tubular Acidosis. [PDF]

Batna Journal of Medical Sciences
Introduction: Rare diseases are those with a prevalence of 1 in 2,000. These include urea cycle disorders (UCDs) and primary distal tubular metabolic acidosis (DTA).
Chahinez NEHAL, Rania AKLI, Ouardia Sofia AIT AISSA, Kenza AIT HAMMOU, Abdelhamid BOUDOUH, Amira AYADI, Sarah FIALA, Fazia DJENNANE   +7 more
doaj   +1 more source

Bicarbonate-dependent pH recovery assays in cultured hRPTCs carrying Wild-Type (WT) or homozygous variant (HV) SLC4A5.

, 2018
A) Bicarbonate-dependent pH recovery: pH recovery was measured in WT and HV SLC4A5 hRPTCs expressing empty vector (vector control, VC), overexpressing (OE) SLC4A5 (4A5OE), knock-down (KD) SLC4A5 (4A5KD), and knock-down (KD) SLC4A4 (4A5KD).
Brandon A. Kemp (5089898), Julia M. Carlson (5089901), Peng Xu (17962), Robin A. Felder (845024), John J. Gildea (845025), Hanh T. Tran (5089883), Helen E. McGrath (5089892), Robert M. Carey (5089886), Pedro A. Jose (191382), Dora Bigler Wang (5089889), Christophe J. Langouët-Astrié (5089895)   +10 more
core   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Ação das soluções de bicarbonato de sódio e fluoretos frente a desafio erosivo e abrasivo, in vitro [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2015.Objetivo: O objetivo deste estudo in vitro foi avaliar os efeitos da solução de bicarbonato de ...
Noschang, Ricardo Augusto Tomaz
core  

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source