Results 161 to 170 of about 1,387,703 (389)

The Effect of THAM and Sodium Bicarbonate on the Oxygen Dissociation Curve and pH Difference Across the Red Cell [PDF]

open access: bronze, 1968
Frederick C. Battaglia   +3 more
openalex   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen   +9 more
wiley   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

open access: yesAdvanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou   +14 more
wiley   +1 more source

Natural Toolbox–Chemical Engineering Aspect and High‐Value Applications of Janus Cellulose Nanomaterials

open access: yesAdvanced Science, EarlyView.
The Tai Ji symbol from China represents the co‐existence of two opposite substances, similar to quantum entanglement. The term Janus comes from ancient Roman religion and mythology. Janus, the god of beginnings, transitions, etc., has two faces, symbolizing duality. Janus cellulose nanomaterials show structural duality.
Yu Zhao   +6 more
wiley   +1 more source

The incorporation of labeled lysine into the proteins of guinea pig liver homogenate [PDF]

open access: yes, 1949
When C14-labeled lysine is incubated with guinea pig liver homogenate, α-aminoadipic, α-ketoadipic, and glutaric acids are formed from the lysine (1). These transformations were established by finding the radioactivity of the C14 tracer in the metabolic ...
Borsook, Henry   +4 more
core  

Halogenation of Ketones. III. The Sodium Acetate and Sodium Bicarbonate Catalyzed Halogenation of Butanone-2. [PDF]

open access: bronze, 1966
Christoffer Rappe   +7 more
openalex   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

open access: yesAdvanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen   +9 more
wiley   +1 more source

The effects of potential organic apple fruit thinners on gas exchange and growth of model apple trees: A model plant study of transient photosynthetic inhibitors and their effect on physiology and growth [PDF]

open access: yes, 2003
Few fruit thinners have been certified for organic fruit growers. Previous studies have shown that herbicides or shade are capable of reducing photosynthesis and are effective fruit-thinning techniques, although impractical. This project evaluated use of
McAfee, Jason D., Rom, Curt C.
core   +2 more sources

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