Results 161 to 170 of about 14,459 (216)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Expedient Discovery of a Metallaphotoredox Cyanomethylation for Synthesizing α‐Aryl Nitriles

Chemistry – A European Journal, EarlyView.
A metallaphotoredox cyanomethylation reaction has been developed for the synthesis of valuable α‐aryl nitrile intermediates. The methodology was successfully applied to diverse medicinally‐relevant substrates, providing an expedient route to anti‐cancer Senexin compounds, while also removing the need for toxic cyanide reagents. The mechanism was probed
Gemma C. Cook, Blandine McKay, Craig Jamieson, Lee J. Edwards, Charlotte Harriman, Zackary S. Read, Simon T. Bate   +6 more
wiley   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Synthesis and characterization of amphiphilic nitroxide 1,1,3,3–tetraethylisoindoline–2–oxyl–5–sodium sulfonate (TEIOSNa)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal, Martha Eugenia Albores Velasco, René O. Vargas, Rubén Mil‐Martínez   +3 more
wiley   +1 more source

Synthesis and characterization of a highly hydrophilic nanocomposite for wettability alteration, water/oil interfacial tension reduction, and enhanced oil recovery

The Canadian Journal of Chemical Engineering, EarlyView.
Mechanism of wettability alteration, interfacial tension reduction, and oil recovery by novel nanocomposite. Abstract The development of stable nanofluids (NFs) for enhanced oil recovery (EOR) relies on optimizing interactions between reservoir rocks and fluids.
Ehsan Jafarbeigi, Ehsan Kamari, Amir H. Mohammadi   +2 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

A Simple Regeneration Process Using a CO2‐Switchable‐Polarity Solvent for Cellulose Hydrogels

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The effect of transformation of the anion chemical structure on cellulose solubility by flowing CO2 gas into aqueous pyrrolidinium hydroxide solutions was investigated. The changes in anion structure allowed for the modulation of cellulose solubility in aqueous pyrrolidinium hydroxide solutions, thus establishing a simple and safe cellulose ...
Arata Matsui, Deandra Ayu Putri, Morgan L. Thomas, Yuko Takeoka, Masahiro Rikukawa, Masahiro Yoshizawa‐Fujita   +5 more
wiley   +1 more source

Mechanistic insights across curing regimes for enzymatic and biopolymer‐optimized reinforcement in rock masses

Deep Underground Science and Engineering, EarlyView.
This study examines the effects of curing temperature on the mechanical behavior of underground rock masses treated with enzyme‐induced calcite precipitation (EICP) and an innovative biopolymer‐modified EICP (BP‐EICP). Abstract Biocementation is an innovative and sustainable technique for reinforcing weak and weathered rock masses in natural and ...
Mary C. Ngoma, Oladoyin Kolawole
wiley   +1 more source

Ag‐Regulated Cu‐Sites on a Conductive Cu‐Metal‐Organic Framework for Enhanced CO2 Electroreduction to CH4

EcoEnergy, EarlyView.
We present a strategy of integrating Ag NPs with a 2D Cu3(HHTP)2 framework to boost selective CO2 electroreduction. The optimal composite achieves 65.1% FECH4 ${\text{FE}}_{{\text{CH}}_{4}}$ at 240 mA cm−2. Synergistic effects enhance CO2 adsorption, facilitate electron transfer, and selectively stabilize key reaction intermediates, steering the ...
Fang‐Fang Wang, Shao‐Xia Wang, Peng Wang, Wei‐Yin Sun   +3 more
wiley   +1 more source

Pd‐Catalyzed Cyclotrimerization and Cycloaddition of 5,6‐Didehydrobenzo[8]annulenes (BenzoCOTynes): Formation of Nonplanar Tri[8]annulenes and Diels–Alder Cycloadducts

European Journal of Organic Chemistry, EarlyView.
A Pd(0)‐catalyzed cyclotrimerization of benzoCOTynes to form tri(benzo[8]annulenes) was developed. Three distinct isomers were isolated and structurally characterized by single‐crystal X‐ray diffraction. Ligand modulation proved crucial for enhancing regioselectivity: P(4‐OMePh), and (S)‐tBu‐Phox promoted the formation of the symmetric isomers.
Jesús Bello‐García, Jesús A. Varela, Carlos Saá   +2 more
wiley   +1 more source