Results 201 to 210 of about 366,375 (330)

Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding

open access: yesAdvanced Science, EarlyView.
Conventional poly(ethylene glycol) (PEG) is commonly applied in biomedicine, but is now known to induce antibody formation. Here, it is shown that the development of “randomized PEG” (rPEG) featuring glycidyl methyl ether (GME) comonomers decreased antibody binding.
Mareike Deuker   +5 more
wiley   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

open access: yesAdvanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su   +18 more
wiley   +1 more source

Reprogrammable Hydroplastic Latex Films and Water‐Driven Phase Separation

open access: yesAdvanced Science, EarlyView.
Hydroplastic latex films with discontinuous hydrophobic phases surrounded by continuous hydrophilic phases, are prepared. Upon immersion in water, the latex films have water‐driven phase separation. ABSTRACT Thermoplastics are a class of plastic polymers that can be remolded repeatedly by heating and cooling.
Yuwei Du, Hanying Zhao
wiley   +1 more source

Thiosulfonate‐Derived BODIPY “Stick and Glue” Strategy for Fluorescent Thiol Labeling

open access: yesAngewandte Chemie, EarlyView.
We present a powerful photochemical strategy for converting disulfide bonds into stable thioether linkages via a [1,2]‐sigmatropic rearrangement. By integrating this reaction into traditional methanethiosulfonate‐based thiol labeling, we enable light‐triggered stabilization of peptide and protein conjugates with enhanced robustness and versatility ...
Lucie Šálková   +4 more
wiley   +2 more sources

Sodium Bicarbonate as an Alternative to Heparin for Catheter Lock in Hemodialysis. [PDF]

open access: yesKidney Int Rep
Sierth R   +3 more
europepmc   +1 more source

Multicentre double-blind randomised placebo-controlled four-arm trial to assess the effect of oral sodium bicarbonate and intravenous hyoscine butylbromide on spontaneous delivery after induction of labour in nulliparous women: protocol for the Safe Induction of Labour Trial (SAINT) [PDF]

open access: gold
Ingvil Krarup Sørbye   +13 more
openalex   +1 more source

Toward Complete CO2 Electroconversion: Status, Challenges, and Perspectives

open access: yesAdvanced Energy Materials, EarlyView.
Electrocatalytic CO2 reduction and CO2 batteries face challenges in achieving complete CO2 conversion with high conversion rates and Faradaic efficiency simultaneously. Existing systems compromise one for the other with incomplete CO2 conversion and inefficiencies, hindering practical applications. This perspective highlights state‐of‐the‐art progress,
Changfan Xu   +5 more
wiley   +1 more source

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