Results 131 to 140 of about 51,216 (289)

Clinical and electrocardiographic predictors of positive response to the intravenous sodium channel blockers in patients suspected of the Brugada syndrome [PDF]

, 2013
Background/objectives: Sodium channel blockers are used to unmask the diagnostic ECG pattern of the Brugada syndrome (BrS) in case of a non-diagnostic baseline ECG. The aim of the study was to determine clinical and ECG predictors of a positive challenge
Fazelifar, A.F., Aslani, A., Khoramshahi, M., Shahrzad, S., Haghjoo, M.   +4 more
core  

A Naphthalimide‐Based NIR‐Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis‐Mediated Antitumor Therapy and Broad‐Spectrum Bacterial Inactivation With Rapid Wound Healing

Advanced Healthcare Materials, EarlyView.
An ionic naphthalimide AIE photosensitizer (PS), TPAPV‐NIM‐M, anchors to cellular and bacterial membranes, emits in the far‐red/near‐infrared (NIR) region, and efficiently generates reactive oxygen species (ROS) under white light. Its membrane‐localized photodynamic action drives apoptosis/ferroptosis‐mediated tumor suppression and broad‐spectrum ...
Sayed Mir Sayed, Zeeshan Tahir, Fahri Alkan, Yavuz Nuri Ertas   +3 more
wiley   +1 more source

Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ‐on‐Chip

Advanced Healthcare Materials, EarlyView.
A novel light‐based bioprinting approach, TVAM‐in‐a‐chip, enables rapid, contactless fabrication of biomimetic 3D organ‐on‐chip devices directly within preassembled microfluidic platforms. This strategy supports diverse materials, including cell‐laden resins, and eliminates post‐assembly steps.
Riccardo Rizzo, Viola Sgarminato, Felix Wechsler, Christophe Moser   +3 more
wiley   +1 more source

Parallels between bipolar disorder and ATP1A3-related diseases: a window into the investigation of lithium for alternating hemiplegia of childhood

Orphanet Journal of Rare Diseases
Background Alternating hemiplegia of childhood (AHC) shares many aspects with the psychiatric condition, bipolar disorder. Body AHC is a heterogeneous genetic disorder that can manifest in various fashions but will usually involve paroxysmal ...
Jacqueline Alves Leite, Leandro Augusto de Oliveira Barbosa, Regina L. Woods, Rif S. El-Mallakh   +3 more
doaj   +1 more source

[Differential pharmacological aspects between voltage-gated sodium channel blockers: implications in clinical practice]. [PDF]

Aten Primaria, 2021
Alcántara Montero A, Pacheco de Vasconcelos SR.   +1 more
europepmc   +1 more source

Vascularization of Human iPSC‐Derived Kidney Organoids Using Perfusion Culture, Pre‐Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix

Advanced Healthcare Materials, EarlyView.
An integrated perfusion‐based culture platform combining pre‐vascularized collagen scaffolds, stromal vascular fraction cells, and kidney decellularized extracellular matrix promotes vascularization of human iPSC‐derived kidney organoids. The platform provides evidence of interactions between vascular networks and glomerular‐like structures and enables
Helen Kearney, Andrea Mazzoleni, Ivan Martin, Lorenzo Moroni, Manuele Giuseppe Muraro, Carlos Mota   +5 more
wiley   +1 more source

Sodium channel blockers in Brugada syndrome [PDF]

EP Europace, 2018
Ibrahim, El-Battrawy, Martin, Borggrefe, Siegfried, Lang, Xiaobo, Zhou, Ibrahim, Akin   +4 more
openaire   +2 more sources

Mechanotransduction of Magnetically Applied Forces Leads to Mechanical Stiffening of Platelet‐Rich Plugs

Advanced Healthcare Materials, EarlyView.
A microfluidic device with magnetic microposts was used to assess platelet mechanobiology. The oscillatory actuation of posts with embedded iron particles was dampened by the dynamic stiffening of the platelet‐rich plugs. This stiffening process increased with applied load, but inhibiting platelet activation (ASA) or myosin contractility (blebbistatin)
Nikita Taparia, Ava M. Obenaus, Yoeur‐Man T. Mach, Nakul Sridhar, Nathan J. Sniadecki   +4 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Voltage-gated sodium channel blockers: new perspectives in the treatment of neuropathic pain

Neurología (English Edition), 2021
A. Alcántara Montero, C.I. Sánchez Carnerero   +1 more
doaj   +1 more source