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Cardiovascular adverse effects of common non-oncologic medications: from mechanisms to clinical management. [PDF]
Eur Heart J Cardiovasc PharmacotherBahit MC +3 more
europepmc +1 more source
Thiazides and Risk of Hyponatremia by Age and Sex.
JAMA Netw OpenBergh Fahlén C +4 more
europepmc +1 more source
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Dibenzazepines and dibenzoxazepines as sodium channel blockers
Bioorganic and Medicinal Chemistry Letters, 2015We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Laykea Tafesse
exaly +3 more sources
Journal of Medicinal Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
openaire +2 more sources
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Donald J, Kyle, Victor I, Ilyin
openaire +2 more sources
Sodium Channel Blockers for the Treatment of Neuropathic Pain [PDF]
Neurotherapeutics, 2009 Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry.
Anindya Bhattacharya, Sandra R Chaplan
exaly +3 more sources
Epilepsy and sodium channel blockers
Expert Opinion on Therapeutic Patents, 2002Epilepsy is one of the most frequent neurological diseases and although most patients nowadays respond well to anti-epileptic drugs (AED), 30 - 40% of them still present seizures despite treatment ...
Daniel Bertrand
exaly +2 more sources
Sodium channel blockers for neuropathic pain
Expert Opinion on Therapeutic Patents, 2010The voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability and their abnormal activity is related to several pathological processes, including cardiac arrhythmias, epilepsy, neurodegenerative diseases, spasticity, chronic and neuropathic pain. In particular, neuropathic pain (e.g., postherpetic and trigeminal
ZULIANI, Valentina +3 more
openaire +3 more sources
Substituted biaryl pyrazoles as sodium channel blockers
Bioorganic and Medicinal Chemistry Letters, 2010Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. A series of low molecular weight biaryl substituted pyrazole carboxamides were identified with good in-vitro potency and in-vivo efficacy. Compound 26, a Nav1.7 blocker has excellent efficacy in the Chung model of neuropathic pain.
Prasun K Chakravarty +2 more
exaly +3 more sources